Cross-Protective Aspects of Glucosyltransferase Antigens in the Hamster Caries Model

  • Daniel J. Smith
  • Martin A. Taubman
  • Jeffrey L. Ebersole
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Recent experiments in rodent (1,2) and primate (3–5) models have indicated that immunization with Streptococcus mutans cells or cell walls can exert a protective influence against subsequent infection with viable cariogenic strains of S. mutans. Protection is observed as diminished colonization by the infecting organisms or reductions in disease on molar surfaces. These mechanisms involve extracellular glucose polymers (glucans) which are synthesized from sucrose by constitutive glucosyltransferase (GTF) enzymes of S. mutans (6). Evidence that protection might be mediated by interference with these mechanisms is indicated by the presence of anti-GTF antibody in the sera and salivas of protected animals following injection with whole S. mutans cells (7–9) and by the demonstration that GTF enzyme function can be immunologically inhibited in vitro (10). Additional evidence comes from immunization experiments in the rodent model in which antigenic preparations containing GTF from serotypes b or g have clearly demonstrated protection from caries caused by infection with homologous strains of S. mutans (11,12).


Infected Group Infection Period Lesion Count Antigenic Relatedness Molar Surface 
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  1. 1.
    Taubman, M. A. and Smith, D. J., Infect. Immun. 9: 1079, 1974.Google Scholar
  2. 2.
    MeGhee, J R., Michalek, S. M., Webb, J., Navia, J. M., Rahman, A.F.R. and Legier, D. W., J. Immunol. 114: 300, 1975.Google Scholar
  3. 3.
    Bowen, W. H., Cohen, B., Cole, M. F. and Coleman, G., Brit. Dent. J. 139: 45, 1975.PubMedCrossRefGoogle Scholar
  4. 4.
    Lehner, T., Challacombe, S. J. and Caldwell, J., Archs. Oral Biol. 20: 305, 1975.CrossRefGoogle Scholar
  5. 5.
    Evans, R. T., Emmings, F. G. and Genco, R. J., Infect. Immun. 12: 293, 1975.PubMedGoogle Scholar
  6. 6.
    Gibbons, R. J. and van Houte, J., Ann. Rev. Micro. 29 : 19, 1975.CrossRefGoogle Scholar
  7. 7.
    Emmings, F. G.,. Evans, R. T. and Genco, R. J., Infect. Immun. 12: 281, 1975.PubMedGoogle Scholar
  8. 8.
    Russell, M. W., Challacombe, S. J. and Lehner, T., Immunology 30: 619, 1975.Google Scholar
  9. 9.
    Genco, R. J., Evans, R. T. and Taubman, M. A., Adv. Exp. Med. Biol. 45: 327, 1975.Google Scholar
  10. 10.
    Fukui, K., Fukui, Y. and Moriyama, T., Infect. Immun. 10: 985. 1974.PubMedGoogle Scholar
  11. 11.
    Hayashi, J. A., Shklair, I. L. and Bahn, A. N., J. Dent. Res. 51: 436, 1972.PubMedCrossRefGoogle Scholar
  12. 12.
    Taubman, M. A. and Smith, D. J., J. Immunol. 118: 710, 1977.PubMedGoogle Scholar
  13. 13.
    Bratthall, D. and Köhler, B., J. Dent. Res. 55: C15, 1976.PubMedCrossRefGoogle Scholar
  14. 14.
    Linzer, R. and Slade, H., Infect. Immun. 13: 494, 1976.PubMedGoogle Scholar
  15. 15.
    Smith, D. J. and Taubman, M. A., Infect. Immun, 15: 91, 1977.PubMedGoogle Scholar
  16. 16.
    Kuramitsu, H. and Ingersoll, L., Infect. Immun. 14: 636, 1976.PubMedGoogle Scholar
  17. 17.
    Smith, D. J., Taubman, M. A. and Ebersole, J. L., J. Dent. Res. 15: A132, 1977.Google Scholar
  18. 18.
    Somogyi, M., J. Biol. Chem. 160: 61, 1945.Google Scholar
  19. 19.
    Keyes, P. H. and Jordan, H. V., Archs. Oral Biol. 9: 377, 1964.CrossRefGoogle Scholar
  20. 20.
    Keene, H. J., Shklair, I. L., Mickel, G. J. and Wirthlin, M. R., J. Dent. Res. 56: 5, 1977.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Daniel J. Smith
    • 1
  • Martin A. Taubman
    • 1
  • Jeffrey L. Ebersole
    • 1
  1. 1.Department of ImmunologyForsyth Dental CenterBostonUSA

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