Influence of Parenteral Immunization in Rabbits on the Penetrability of Oral Mucosa for Macromolecules
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Enhanced respiratory immunity has been observed in parenterally immunized animals after irritant-induced extravasation of circulating antibodies into nasopharyngeal mucosa and secretions (9, 10). This phenomenon has been termed “pathotopic’potentiation” of local immunity. It is possible that crevicular fluid may be regarded as an aspect of pathotopic potentiation of gingival defense mechanisms. Recent animal experiments indicated that antibodies present intercellularly in the gingival crevicular epithelium restricted the penetration of topically applied antigen (19). Moreover, gnotobiotic rats immunized parenterally with antigens from Actinomyces viscosus responded to dental plaque produced by this microorganism with a relatively small inflammatory infiltrate compared to control animals (13). A similarly reduced inflammatory response to initial plaque formation was observed in dogs after parenteral immunization with antigens extracted from plaque grown in animals kept on a soft diet (22). The authors concluded that serum-derived antibodies might have hampered the diffusion of bacterial antigens through the crevicular epithelium.
KeywordsOral Mucosa Lysosomal Enzyme Dental Plaque Streptococcus Mutans Human Albumin
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