Influence of Parenteral Immunization in Rabbits on the Penetrability of Oral Mucosa for Macromolecules

  • Per Brandtzaeg
  • Kåre Tolo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Enhanced respiratory immunity has been observed in parenterally immunized animals after irritant-induced extravasation of circulating antibodies into nasopharyngeal mucosa and secretions (9, 10). This phenomenon has been termed “pathotopic’potentiation” of local immunity. It is possible that crevicular fluid may be regarded as an aspect of pathotopic potentiation of gingival defense mechanisms. Recent animal experiments indicated that antibodies present intercellularly in the gingival crevicular epithelium restricted the penetration of topically applied antigen (19). Moreover, gnotobiotic rats immunized parenterally with antigens from Actinomyces viscosus responded to dental plaque produced by this microorganism with a relatively small inflammatory infiltrate compared to control animals (13). A similarly reduced inflammatory response to initial plaque formation was observed in dogs after parenteral immunization with antigens extracted from plaque grown in animals kept on a soft diet (22). The authors concluded that serum-derived antibodies might have hampered the diffusion of bacterial antigens through the crevicular epithelium.


Oral Mucosa Lysosomal Enzyme Dental Plaque Streptococcus Mutans Human Albumin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    André, C., Lambert, R., Bazin, H. and Heremans, J. F., Eur. J. Immun. 4: 701, 1974.CrossRefGoogle Scholar
  2. 2.
    Auer, J., J. Exp. Med. 32: 427, 1920.PubMedCrossRefGoogle Scholar
  3. 3.
    Bellamy, J.E.C. and Nielsen, O., Infect. Immun. 9: 615, 1974.PubMedGoogle Scholar
  4. 4.
    Brandtzaeg, P., in Oral Mucosa in Health and Disease (Edited by Dolby, A. E), p. 137, Blackwell Scientific Publications, Oxford, 1975.Google Scholar
  5. 5.
    Brandtzaeg, P. and Baklien, K., Scand. J. Gastroenterol. 11: (Suppl. 36), 1, 1976.Google Scholar
  6. 6.
    Brandtzaeg, P. and Tolo, K., Nature 266: 262, 1977.PubMedCrossRefGoogle Scholar
  7. 7.
    Cardella, C. J., Davies, P. and Allison, A. C., Nature 247: 46, 1974.PubMedCrossRefGoogle Scholar
  8. 8.
    Cochrane, C., J. Invest. Dermatol. 64: 301, 1975.PubMedCrossRefGoogle Scholar
  9. 9.
    Fazekas de St, Groth, S., Austral. J. Exp. Biol. Med. Sci. 29: 339, 1951.CrossRefGoogle Scholar
  10. 10.
    Fazekas de St., Groth, S., Donnelley, M. and Graham, D. M., Austral. J. Exp. Biol. Med. Sci. 29: 323, 1951.CrossRefGoogle Scholar
  11. 11.
    Ford, H. and Kirsner, J. B., Proc. Soc. Exp. Biol. Med. 116: 745, 1964.PubMedGoogle Scholar
  12. 12.
    Goldstein, I. M., Prog. Allergy 20: 305, 1976.Google Scholar
  13. 13.
    Guggenheim, B. and Schroeder, H. E., Infect. Immun. 10: 565, 1974.PubMedGoogle Scholar
  14. 14.
    Kraft, S. C., Fitch, F. W. and Kirsner, J. B., Am. J. Pathol. 43: 913, 1963.PubMedGoogle Scholar
  15. 15.
    Lehner, T., Challacombe, S. J. and Caldwell, J., Nature 254: 517, 1975.PubMedCrossRefGoogle Scholar
  16. 16.
    Lönsman Poulsen, H., Scand. J. Clin. Lab. Invest. 34: 119, 1974.CrossRefGoogle Scholar
  17. 17.
    McArthur, W. R., Baehni, P. and Taichman, N. S., Infect. Immun. 14: 1315, 1976.PubMedGoogle Scholar
  18. 18.
    McDougall, W. A., J. Periodont. Res. 7: 304, 1972.CrossRefGoogle Scholar
  19. 19.
    McDougall, W. A., J. Periodont. Res. 9: 153, 1974.PubMedCrossRefGoogle Scholar
  20. 20.
    Michalek, S. M., McGhee, J. R., Mestecky, J., Arnold, R. R. and Bozzo, L., Science 192: 1238, 1976.PubMedCrossRefGoogle Scholar
  21. 21.
    Orstavik, D. and Brandtzaeg, P., Scand. J. Dent. Res. 85: 106, 1977.PubMedGoogle Scholar
  22. 22.
    Rylander, H., Lindhe, J. and Ahlstedt, S., J. Periodont. Res. 11: 339, 1976.PubMedCrossRefGoogle Scholar
  23. 23.
    Tolo, K., Brandtzaeg, P. and Jonsen, J., Immunology, 33: 733, 1977.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Per Brandtzaeg
    • 1
    • 2
  • Kåre Tolo
    • 1
    • 2
  1. 1.Histochemical LaboratoryInstitute of PathologyNorway
  2. 2.Department of Periodontics, Dental FacultyUniversity of OsloNorway

Personalised recommendations