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I wondered if Dr. Mestecky or Dr. McGhee could address themselves to the question that concerns the universality of seeding of various glands by the stimulated cells. Let’s say you have a local mucosal respiratory infection with the respiratory syncytial virus. According to the various hypotheses that have been put forth today and the data that we have seen, one might expect an antibody response to that virus, for example, in the kidney. We know that there are organisms which characteristically infect certain sites and not others. What would be the teleological advantage of having a system, in which a response is induced at a particular site, and which is then seeded to all other sites, which that organism would never infect? In other words, could there be an element of specificity here? Are we generalizing too early in terms of all antibodies going to all sites? If there is an element of specificity, if only certain antibodies go to certain sites where they are really needed, how is the element inserted? I suggest the possibility — could it be inserted by the antigen? Is it possible that antigen is actually carried in some form which is not easily detectable on the surface or inside of a lymphocyte?
KeywordsSalivary Gland Respiratory Syncytial Virus Cervical Lymph Node Thoracic Duct Mucosal Site
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