Secretory IgA Antibodies to Enterobacterial Virulence Antigens: Their Induction and Possible Relevance

  • L. Å. Hanson
  • S. Ahlstedt
  • B. Carlsson
  • B. Kaijser
  • P. Larsson
  • I. Mattsby Baltzer
  • A. Sohl Åkerlund
  • C. Svanborg Edén
  • A.-M. Svennerholm
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


The existence of local antibody-mediated immunity has been known for several decades (1–4). Knowledge about the special properties of secretory IgA (s-IgA) antibodies has defined antibody-mediated local immunity as an entity different and separate from systemic antibody-mediated immunity (5–7). The induction and role of s-IgA antibodies to virulence antigens of microbes infecting various mucous surfaces is now being studied and elucidated. The finding of Craig and Cebra (8) that Peyer’s patch lymphocytes can repopulate the intestinal mucosa of irradiated animals with IgA producing cells suggested that such cells may migrate also to other submucosal sites. New information has recently been added in this field by investigations on the migration, “homing”, of IgA producing cells from the Peyer’s patches to various exocrine glands (9,10). This brief review deals with the relation between the homing mechanism and the appearance and possible role of s-IgA antibodies to enterobacterial antigens in milk, saliva, urine and bronchial secretion.


Human Milk Acute Pyelonephritis Cholera Vaccine Pakistani Woman Serum Antibody Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Besredka, A., in Local Immunization, Williams and Wilkins, Baltimore, 1927.Google Scholar
  2. 2.
    Burrows, W. and Havens, I., J. Infect. Dis. 82: 231, 1948.PubMedCrossRefGoogle Scholar
  3. 3.
    Fazekas de St., Groth, S., Donnelley, M. and Graham, D. M., Aust. J. Exp. Biol. Med. Sci. 29: 323, 1951.CrossRefGoogle Scholar
  4. 4.
    Fazekas de St, Groth, S., Aust. J. Exp. Biol. Med. Sci. 29: 339, 1951.CrossRefGoogle Scholar
  5. 5.
    Tomasi, T. B. and Bienenstock, J., in Advances in Immunology, Vol. IX, (Edited by Dixon, F. J. and Kunkel, H. G.), p. 1, Academic Press, New York, 1968.CrossRefGoogle Scholar
  6. 6.
    Heremans, J. F., in The Antigens, Vol. II, (Edited by Sela, M.), p. 365, Academic Press, New York, 1974.Google Scholar
  7. 7.
    Hanson, L. Å. and Brantzaeg, P., in Immunologic Disorders in Infants and Children, (Edited by Stiehm, E. R. and Fulginiti, V. A.), p. 107, W. B. Saunders, Philadelphia, 1973 (2nd ed. in press).Google Scholar
  8. 8.
    Craig, S. W. and Cebra, J. J., J. Exp. Med. 134: 188, 1971.PubMedCrossRefGoogle Scholar
  9. 9.
    Goldblum, R. M., Ahlstedt, S., Carlsson, B., Hanson, L. Å., Jodal, J., Lidin-Janson, G. and Sohl, A., Nature 257: 797, 1975.PubMedCrossRefGoogle Scholar
  10. 10.
    Roux, M., McWilliams, M., Phillips-Quagliata, J. M., Weisz-Carrington, P. and Lamm, M. E. (in manuscript).Google Scholar
  11. 11.
    Freter, R. and Jones, G. W., Infect. Immun. 14: 246, 1976.PubMedGoogle Scholar
  12. 12.
    Pierce, N. F. and Sack, R. B., J. Infect. Dis. 136 Suppl. Aug.: S 113, 1977.CrossRefGoogle Scholar
  13. 13.
    Holmgren, J. and Svennerholm, A.-M., J. Infect. Dis. 136 Suppl. Aug.: S 105, 1977.CrossRefGoogle Scholar
  14. 14.
    Jodal, U., Ahlstedt, S., Carlsson, B., Hanson, L. Å., Lindberg, U. and Sohl, A., Int. Arch. Allergy 47: 537, 1974.PubMedCrossRefGoogle Scholar
  15. 15.
    Sohl Åkerlund, A., Ahlstedt, S., Hanson, L. Å., Lindberg, U. and Oiling, S., Int. Arch. Allergy (in press).Google Scholar
  16. 16.
    Carlsson, B., Gothefors, L., Ahlstedt, S., Hanson, L. Å. and Winberg, J., Acta Paediatr. Scand. 65: 216, 1976.PubMedCrossRefGoogle Scholar
  17. 17.
    Gindrat, J. J., Gothefors, L., Hanson, L. Å. and Winberg, J., Acta Paediatr. Scand. 61:587, 1972.PubMedCrossRefGoogle Scholar
  18. 18.
    Ahlstedt, S., Carlsson, B. Fällström, S. P. Hanson, L. Å. Holmgren, J. Lidin-Janson, G. Lindblad, B. S. Jodal, U. Kaijser, B. Sohl Åkerlund, A. and Wadsworth, C., in Immunology in the Gut, CIBA Foundation Symposium 46, p. 115, Elsevier/Excerpta Medica/North Holland, 1977.Google Scholar
  19. 19.
    McCracken, G. H., Sarff, L. B., Robbins, J. B., Glode, M., Kaijser, B. and Hanson, L. Å., Ped. Res. 4:401, 1976.Google Scholar
  20. 20.
    Holmgren, J., Hanson, L. Å., Carlsson, B., Lindblad, B. S. and Rahimtoola, J., Scand. J. Immunol. 5: 867, 1976.PubMedCrossRefGoogle Scholar
  21. 21.
    Svennerholm, A.-M., Holmgren, J., Hanson, L. Å., Lindblad, B. S., Quereshi, F. and Rahimtoola, J., Scand. J. Immunol. (in press).Google Scholar
  22. 22.
    Ahlstedt, S., Carlsson, B., Hanson, L. Å. and Goldblum, R. M., Scand. J. Immunol. 4: 535, 1975.PubMedCrossRefGoogle Scholar
  23. 23.
    Lodinová, R., Jonja, V. and Wagner, V., Paediatr. Res. 7: 659, 1973.CrossRefGoogle Scholar
  24. 24.
    Carlsson, B., Meitert, T., Garon, E., Cogulescu, L. and Hanson, L. Å. (in manuscript).Google Scholar
  25. 25.
    Meitert, T., Istrati, G., Sulea, I. T., Baron, E., Andronescu, C., Cogulescu, L., Templea, C., Ianopol, L., Galau, L., Fleserin, H., Onciu, C., Bogos, L., Lupovici, R., Boghoitoin, G.-H., Ohmt, E., Popescu, G. H., Mihailiuc, I., Mastey, S., Tapu, S. and Zebreniuc, D., Arch. Rum. Path. Exp. Microbiol. 1: 35, 1973.Google Scholar
  26. 26.
    Montgomery, P. C., Rosner, B. R. and Cohn, J., Immun. Commun. 3 : 143, 1974.Google Scholar
  27. 27.
    Hanson, L. Å., Ahlstedt, S., Carlsson, B., Jodal, U., Lindberg, U. and Sohl, A., in The Immunoglobulin A System (Edited by Mestecky, J. and Lawton, A. R.), p. 399, Plenum Publishing Corp., New York, 1974.CrossRefGoogle Scholar
  28. 28.
    Sohl Åkerlund, A., Ahlstedt, S., Hanson, L. Å. and Jodal, U. (in manuscript).Google Scholar
  29. 29.
    Kunin, C. M., New Engl. J. Med. 282: 1143, 1970.Google Scholar
  30. 30.
    Kaijser, B., Larsson, P. and Oiling. S. (submitted to Infect. Immun.).Google Scholar
  31. 31.
    Rudzik, R., Clancy, R. L., Perey, D.Y.E., Day, R. P. and Bienenstock, J., J. Immunol. 114:1599, 1975.PubMedGoogle Scholar
  32. 32.
    André, C., Lambert, R., Bazin, H. and Heremans, J. F., Eur. J. Immunol. 4: 701, 1974.PubMedCrossRefGoogle Scholar
  33. 33.
    Thomas, H. C. and Parrot, D.M.V., Immunology 27: 631, 1974.PubMedGoogle Scholar
  34. 34.
    André, C., Chalon, M. -P., and Vaerman, J. -P., in Protides of Biological Fluids, Vol. 25, (Edited by Peeters, H.), Pergamon Press, Oxford (in press).Google Scholar
  35. 35.
    Bullen, J. J., Rogers, H. J. and Leigh, L., Brit. Med. J. 1: 69, 1972.PubMedCrossRefGoogle Scholar
  36. 36.
    Fubara, E. S. and Freter, R., J. Immunol. 111: 395, 1973.PubMedGoogle Scholar
  37. 37.
    Gibbons, R. J. and van Houte, J., Ann. Rev. Microbiol. 501: 19, 1975.CrossRefGoogle Scholar
  38. 38.
    McNeish, A. S., Turner, P., Fleming, J. and Evans, N., Lancet II : 946, 1975.CrossRefGoogle Scholar
  39. 39.
    Svanborg, Edén, C., Hanson, L. Å., Jodal, U., Lindberg, U. and Sohl Åkerlund, A., Lancet II: 490, 1976.Google Scholar
  40. 40.
    Svanborg, Edén, C., Eriksson, B. and Hanson, L. Å., Infect. Immun, (in press).Google Scholar
  41. 41.
    Svanborg, Edén, C. and Hanson, L. A., (submitted to Infect. Immun.).Google Scholar
  42. 42.
    Hanson, L. Å., Ahlstedt, S., Fasth, A., Jodal, U., Kaijser, B., Larsson, P., Lindberg, U., Oiling, S., Sohl Åkerlund, A. and Svanborg Edén, C., J. Infect. Dis. 136 Suppl.: S 144, 1977.Google Scholar
  43. 43.
    Oiling, S., Scand. J. Infect. Dis., Vol. IX, Suppl. 10, 1977.Google Scholar
  44. 44.
    Lindberg, U., Hanson, L. Å., Jodal, U., Lidin-Janson, G., Lincoln, K. and Oiling, S., Acta Paediatr. Scand. 64: 432, 1975.PubMedCrossRefGoogle Scholar
  45. 45.
    Kaijser, B., Hanson, L. Å., Jodal, U., Lidin-Janson, G. and Robbins, J. B., Lancet 1: 663, 1977.PubMedCrossRefGoogle Scholar
  46. 46.
    Lindberg, U., Claësson, I., Hanson, L. Å. and Jodal, U., J. Ped., 1977 (in press).Google Scholar
  47. 47.
    Sack, R. B. and Miller, C. E., J. Bacteriol. 99: 688, 1969.PubMedGoogle Scholar
  48. 48.
    Svennerholm, A. -M., Lange, S. and Holmgren, J. (in manuscript).Google Scholar
  49. 49.
    Mata, L. J. and Urrutia, J. J., Ann. N. Y. Acad. Sci. 176: 93, 1971.CrossRefGoogle Scholar
  50. 50.
    Goldman, A. S. and Smith, W. C., J. Ped. 82: 1082, 1973.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • L. Å. Hanson
    • 1
  • S. Ahlstedt
    • 1
  • B. Carlsson
    • 1
  • B. Kaijser
    • 1
  • P. Larsson
    • 1
  • I. Mattsby Baltzer
    • 1
  • A. Sohl Åkerlund
    • 1
  • C. Svanborg Edén
    • 1
  • A.-M. Svennerholm
    • 1
  1. 1.Department of Immunology and Department of General Bacteriology, Institute of Medical Microbiology and Department of PediatricsUniversity of GöteborgGöteborgSweden

Personalised recommendations