Cellular Aspects of the Murine Anti-Hapten IgA Response

  • Edward T. Lally
  • Ian M. Zitron
  • Richard C. Fiorini
  • Paul C. Montgomery
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 107)


Early experiments established the requirement for thymus derived (T) lymphocytes and bone marrow derived (B) lymphocytes for the generation of humoral antibody responses (1–3). In recent years our knowledge of the regulatory functions of T-cells with respect to B-cell differentiation has been expanded to reveal an intricate system, which in addition to cells, involves regulator genes and soluble factors (reviewed 4,5). The regulatory influence which T-cells exert on the stimulation of IgM, IgG (4,5) and more recently, IgE (6–8) is well defined. A similar understanding of the regulatory effect of T-cells on the IgA response would be useful in understanding the development of the secretory immune response.


Bone Marrow Cell Adoptive Transfer Thymus Cell Plaque Form Cell Myeloma Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Claman, H. N., Chaperon, E. A. and Triplett, R. F., Proc. Soc. Exp. Biol. (N.Y.) 122: 1167, 1966.Google Scholar
  2. 2.
    Davies, A.J.S., Leuchers, E., Wallis, V., Marchant, R. and Elliot, E. V., Transplantation 5: 222, 1967.CrossRefGoogle Scholar
  3. 3.
    Miller, J.A.F.P., Brunner, K. T., Sprent, J., Russel, P. J. and Mitchell, G. F., Transplant. Proc. 3: 915, 1971.PubMedGoogle Scholar
  4. 4.
    Katz, D. H. and Benacerraf, B., Adv. Immunol. 15: 1, 1972.PubMedCrossRefGoogle Scholar
  5. 5.
    Miller, J.A.F.P. and Mitchell, G. T., Transplant. Rev. 1: 3, 1969.PubMedGoogle Scholar
  6. 6.
    Tada, T. and Okumura, K., J. Immunol. 107: 1137, 1971.PubMedGoogle Scholar
  7. 7.
    Kishimoto, T. and Ishizaka, K., J. Immunol. 109: 612, 1972.PubMedGoogle Scholar
  8. 8.
    Hamaoka, T., Katz, D. H. and Benacerraf, B. , J. Exp. Med. 138: 583, 1973.Google Scholar
  9. 9.
    Crewther, P. and Wainer, N. L., Aust. J. Exp. Biol. Med. Sci. 50: 625, 1972.PubMedCrossRefGoogle Scholar
  10. 10.
    Luzzati, A. L. and Jacobson, E. B., Eur. J. Immunol. 2: 473, 1972.PubMedCrossRefGoogle Scholar
  11. 11.
    Pritchard, H., Riddaway, J. and Micklem, H. S., Clin. Exp. Immunol. 13: 25, 1973.Google Scholar
  12. 12.
    Perey, D.Y.E. and Bienenstock, J., J. Immunol. 111: 633, 1973.PubMedGoogle Scholar
  13. 13.
    Clough, J. D., Mims, L. H. and Stroben, W., J. Immunol. 106: 1624, 1971.PubMedGoogle Scholar
  14. 14.
    Stobo, J. D. and Tomasi, T. B., J. Clin. Invest. 46: 1329, 1967.PubMedCrossRefGoogle Scholar
  15. 15.
    McFarlin, D. E., Stroben, W. and Waldman, T. A., Medicine 51: 281, 1972.PubMedCrossRefGoogle Scholar
  16. 16.
    Eisen, H. N., in Methods in Medical Research (Edited by Eisen, H. N.), Vol. 10, p. 94, Year Book Medical Publishers, Chicago, 1974.Google Scholar
  17. 17.
    Proom, H., J. Path. Bact. 55: 419, 1943.CrossRefGoogle Scholar
  18. 18.
    Fahey, J., in Methods in Immunology and Immunochemistry (Edited by Williams, C. A. and Chase, M. W.), Vol. 1, p. 320, Academic Press, New York, 1967.Google Scholar
  19. 19.
    Goetzl, E. and Metzger, H., Biochemistry 9: 1267, 1970.PubMedCrossRefGoogle Scholar
  20. 20.
    Jerne, N. K. and Nordin, A. A., Science, 140: 405, 1963.CrossRefGoogle Scholar
  21. 21.
    Mishell, R. J. and Dutton, R. W., J. Exp. Med. 126: 423, 1967.PubMedCrossRefGoogle Scholar
  22. 22.
    Rittenberg, M. B. and Pratt, K. L., Proc. Soc. Exp. Biol. Med. 132: 575, 1969.PubMedGoogle Scholar
  23. 23.
    Walters, C. S. and Jackson, A. J., J. Immunol. 101: 541, 1968.PubMedGoogle Scholar
  24. 24.
    Sell, S., Park, A. B. and Nordin, A.A., J. Immunol. 104: 483, 1970.PubMedGoogle Scholar
  25. 25.
    Mauch, P., Bridges, S. H. and Little, K.D., J. Immunol. 112: 812, 1974.PubMedGoogle Scholar
  26. 26.
    Ogra, P. L. and Karzon, D. T., J. Immunol. 102: 15, 1969.PubMedGoogle Scholar
  27. 27.
    Andre, C., Bazin, H. and Heremans, J. D., Digestion 9: 166, 1973.PubMedCrossRefGoogle Scholar
  28. 28.
    Thomas, H. C. and Parrott, D.M.V., Immunology 27: 631, 1974.PubMedGoogle Scholar
  29. 29.
    Nossal, G.J.V. and Schrader, J. W., Transplant. Rev. 23: 138, 1975.PubMedGoogle Scholar
  30. 30.
    Andre, C., Lambert, R., Bazin, H. and Heremans, J. F., Eur. J. Immunol. 4: 701, 1974.PubMedCrossRefGoogle Scholar
  31. 31.
    Stokes, C. R., Soothill, J. F. and Turner, M. W., Nature 255: 745, 1975.PubMedCrossRefGoogle Scholar
  32. 32.
    Cebra, J. J., Gearhart, P. J., Kamat, R., Robertson, S. M. and Tseng, J., Cold Spring Harb. Symp. Quant. Biol. 41: 201, 1976.CrossRefGoogle Scholar
  33. 33.
    Allison, A. C. and Davies, A.J.S., Nature 233: 330, 1971.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Edward T. Lally
    • 1
  • Ian M. Zitron
    • 2
  • Richard C. Fiorini
    • 3
  • Paul C. Montgomery
    • 3
  1. 1.Department of Pathology, School of Dental Medicine and Center for Oral Health ResearchUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of PathologyJewish Hospital of St. Louis and Washington University School of MedicineSt. LouisUSA
  3. 3.Department of Microbiology, School of Dental Medicine and Center for Oral Health ResearchUniversity of PennsylvaniaPhiladelphiaUSA

Personalised recommendations