Abstract
Circulating antibodies against a variety of environmental antigens (1–6) appear in normal individuals after lymphoid tissues associated with mucosal surfaces are exposed to either the homologous or cross-reacting antigens. This immunization is one of the physiologic means by which mammals acquire protection against potential pathogens during early infancy (6–8). Prior to the development of such active immunity, the newborn is protected against the potentially harmful effects of these antigens by antibodies passively acquired from the mother. However, passive immunity may either suppress or enhance active immune responses, depending on quantitative factors and temporal relationships between the administration of antibody and the first exposure to the antigen (9). An understanding of the effects of passively transferred antibody on the amount and quality of antibody actively produced following the ingestion of antigen may provide insight into the effects of placentally transferred specific antibody on the immune response to the homologous antigen ingested during infancy.
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Rothberg, R.M., Rieger, C.H.L., Kraft, S.C., Lustig, J.V. (1978). Development of Humoral Antibody Following the Ingestion of Soluble Protein Antigen by Passively Immunized Animals. In: McGhee, J.R., Mestecky, J., Babb, J.L. (eds) Secretory Immunity and Infection. Advances in Experimental Medicine and Biology, vol 107. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3369-2_15
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DOI: https://doi.org/10.1007/978-1-4684-3369-2_15
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