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Transport of Short Chain Fatty Acids

  • Chapter
Intestinal Absorption

Part of the book series: Biomembranes ((B,volume 4B))

Abstract

The present interest in the mechanisms involved in intestinal transport of short-chain fatty acids (SCFA) derives from the experiments of Smyth and Taylor [1,2] which showed that compounds of this type were transported against gradients of concentration from luminal to serosal sides of rat intestine incubated in vitro. The nutritional significance of SCFA in the metabolic economy of ruminants is well established [3], and the mechanisms involved in the absorption of SCFA from the rumen have been extensively investigated [4, 5]. Significant concentrations of SCFA also occur within the alimentary tract of rodents [6, 7, 8] and the hen [9, 10]. Although evidence for the absorption of endogenous SCFA from the intestines of non-ruminants has been presented [11, 12, 13], and exogenous SCFA are utilized with high efficiency when fed to rats [14, 15], recent studies suggest that the contribution of SCFA to the metabolism of rats may be small [16]. Thus studies of SCFA transport in the intestines of non-ruminants do not have the background of unequivocal nutritional relevance which supports analogous studies in this area, but such studies have provided information concerning several aspects of intestinal epithelial cell function which are of general interest.

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References

  1. D. H. Smyth and C. B. Taylor, J. Physiol 136, 633 (1957).

    Google Scholar 

  2. D. H. Smyth and C. B. Taylor, J. Physiol., 141, 73 (1958).

    PubMed  CAS  Google Scholar 

  3. K. L. Blaxter, The energy metabolism of ruminants, Charles C. Thomas, Springfield (1962).

    Google Scholar 

  4. E. F. Annison and D. Lewis, Metabolism in the rumen, Methuen, London (1959).

    Google Scholar 

  5. A. Dobson and A. T. Phillipson (C. F. Code, ed.), Alimentary Canal, Vol. 5, Bile; Digestion; Ruminal Physiology, p. 2761, American Physiological Society, Washington D.C. (1968).

    Google Scholar 

  6. S. R. Elsden, M. W. S. Hitchcock, R. A. Marshall and A. T. Phillipson, J. exptl Biol., 22, 191 (1946).

    CAS  Google Scholar 

  7. M. G. Yang, K. Monoharan and A. K. Young, J. Nutr., 97, 260 (1969).

    PubMed  CAS  Google Scholar 

  8. S. J. Henning and F.J. R. Hird, Brit. J. Nutr., 24, 145 (1970).

    Article  CAS  Google Scholar 

  9. E. Watanabe, Med. Biol, 70, 283 (1965).

    Google Scholar 

  10. E. Watanabe and A. Chiba, Jap. J. Zootech. Sci., 40, 180 (1969).

    Google Scholar 

  11. J. Barcroft, R. A. McAnally and A. T. Phillipson, J. exptl Biol, 20, 120 (1944).

    CAS  Google Scholar 

  12. E. Watanabe, Med. Biol, 72, 263 (1966).

    CAS  Google Scholar 

  13. E. Watanabe and A. Chiba, Med. Biol, 78, 227 (1969).

    CAS  Google Scholar 

  14. C. O. Little and G. E. Mitchell, Life Sci., 4, 905 (1965).

    Article  PubMed  CAS  Google Scholar 

  15. J. W. McActee, C. O. Little and G. E. Mitchell, Life Sci, 7, 769 (1968).

    Article  Google Scholar 

  16. M. G. Yang, K. Manoharan and O. Michelsen, J. Nutr., 100, 545 (1970).

    PubMed  CAS  Google Scholar 

  17. P. R. Holt (G. B. J. Glass, Editor), Progress in Gastroenterology, Vol. 1, p. 277, Gruñe and Stratton, New York (1968).

    Google Scholar 

  18. H. S. Raper, J. biol Chem., 14, 117 (1913).

    CAS  Google Scholar 

  19. R. H. Hughes and E. J. Wimmer, J. biol. Chem., 108, 141 (1935).

    CAS  Google Scholar 

  20. J. Fernandes, J. H. Van de Kamer and H. A. Weijers, J. clin. Invest., 34, 1026 (1955).

    Article  PubMed  CAS  Google Scholar 

  21. R. Blomstrand, N. A. Thorn and E. H. Ahrens, Amer. J. Med., 24, 958 (1958).

    Article  PubMed  CAS  Google Scholar 

  22. B. Bloom, I. Chaikoff and W. O. Reinhardt, Amer. J. Physiol., 166, 451 (1951).

    PubMed  CAS  Google Scholar 

  23. J. J. Gottenbos and H. J. Thomasson, Acta physiol. pharm. neerl., 12, 288 (1964).

    Google Scholar 

  24. J. Y. Kiyasu, B. Bloom and I. L. Chaikoff, J. biol. Chem., 199, 415 (1952).

    PubMed  CAS  Google Scholar 

  25. B. Borgstrom, Acta physiol. scand., 34, 71 (1955).

    Article  PubMed  CAS  Google Scholar 

  26. G. Clement, J. Clement, R. Courel, J. Klepping and S. Briet, Biochemical Problems of Lipids (A. C. Frazer, ed.), p. 172, Elsevier, New York (1963).

    Google Scholar 

  27. S. A. Hashim, S. S. Bergen, K. Krell and T. B. van Itallie, J. clin. Invest., 43, 1238 (1964).

    Google Scholar 

  28. S. A. Hyun, G. V. Vahouny and C. R. Treadwell, Biochim. biophys. acta, 137, 296 (1967).

    Article  PubMed  CAS  Google Scholar 

  29. R. Blomstrand, Acta physiol. scand., 34, 67 (1955).

    Article  PubMed  CAS  Google Scholar 

  30. A. C. Frazer, Physiol. Rev., 26, 103 (1946).

    PubMed  CAS  Google Scholar 

  31. A. C. Frazer, J. Physiol., 102, 329 (1943).

    PubMed  CAS  Google Scholar 

  32. A. M. Dawson, N. Gallagher, D. R. Saunders and J. Webb, Metabolism and Physiological Significance of Lipids, (R. M. C. Dawson and D. N. Rhodes, eds.), P. 243, Wiley, New York (1964).

    Google Scholar 

  33. N. Gallagher, J. Webb and A. M. Dawson, Clin. Sci, 29, 73 (1965).

    PubMed  CAS  Google Scholar 

  34. S. B. Clark and P. R. Holt, J, clin. Invest, 47, 612 (1968).

    Article  CAS  Google Scholar 

  35. W. O. Dobbins and E. L. Rollins, J. Ultrastruct. Res., 33, 29 (1970).

    Article  PubMed  CAS  Google Scholar 

  36. J. Senior and K. J. Isselbacher, Biochim. biophys. acta, 44, 399 (1960).

    Article  PubMed  CAS  Google Scholar 

  37. G. Ailhaud, L. Sarda and P. Desnuelle, Biochim. biophys. acta, 59, 261 (1962).

    Article  PubMed  CAS  Google Scholar 

  38. D. N. Brindley and G. Hubscher, Biochim. biophys. acta, 125, 92 (1966).

    Article  PubMed  CAS  Google Scholar 

  39. J. R. Senior and K. J. Isselbacher, J. clin. Invest., 42, 187 (1963).

    Article  PubMed  CAS  Google Scholar 

  40. M. R. Playoust and K. J. Isselbacher, J. clin. Invest., 43, 878 (1964).

    Article  PubMed  CAS  Google Scholar 

  41. R. J. C. Barry, M. J. Jackson and D. H. Smyth, J. Physiol, 185, 667 (1966).

    PubMed  CAS  Google Scholar 

  42. J. Howard, M. J. Jackson and D. H. Smyth, J. Physiol, 208, 461 (1970).

    PubMed  CAS  Google Scholar 

  43. J. F. Mead, D. R. Howton and J. C. Nevenzel, Comprehensive Biochemistry, Vol. 6, Lipids and Amino Acids and Related Compounds, (M. Florkin and E. H. Stotz, eds.), p. 18, Elsevier, New York (1965).

    Google Scholar 

  44. E. L. Coe, Nature, 211, 80 (1966).

    Article  PubMed  CAS  Google Scholar 

  45. R.J. C. Barry and D. H. Smyth, J. Physiol, 152, 48 (1960).

    PubMed  CAS  Google Scholar 

  46. R. J. C. Barry, M. J. Jackson and D. H. Smyth, J. Physiol, 182, 150 (1966).

    PubMed  CAS  Google Scholar 

  47. S. G. Schultz and P. F. Curran, Physiol Rev., 50, 637 (1970).

    PubMed  CAS  Google Scholar 

  48. H. J. Deuel, L. Hallman and A. Reifman, J. Nutr., 21, 373 (1941).

    CAS  Google Scholar 

  49. M. Enser, Biochem. J., 93, 290 (1964).

    PubMed  CAS  Google Scholar 

  50. R. B. Zurier, J. F. Patterson and R. Levitan, Amer. J. dig. Dis., 13, 109 (1968).

    Article  PubMed  CAS  Google Scholar 

  51. T. W. Clarkson, A. Rothstein and A. Cross, Amer. J. Physiol 200, 781 (1961).

    PubMed  CAS  Google Scholar 

  52. H. H. Ussing, Acta physiol. scand., 19, 43 (1949).

    Article  CAS  Google Scholar 

  53. L. S. Schanker, D. J. Tocco, B. B. Brodie and C. A. M. Hogben, J. Pharmacol, 123, 81 (1958).

    CAS  Google Scholar 

  54. C. A. M. Hogben, D. J. Tocco, B. B. Brodie and L. S. Schanker, J. Pharmacol, 125, 275 (1959).

    CAS  Google Scholar 

  55. C. A. M. Hogben, Ann. Rev. Physiol, 22, 381 (1960).

    Article  CAS  Google Scholar 

  56. W.J. V. Osterhout, J. gen. Physiol, 8, 131 (1925).

    Article  PubMed  CAS  Google Scholar 

  57. T. Teorell, Skand. Arch. Physiol, 66, 225 (1933).

    Article  CAS  Google Scholar 

  58. R. C. Ingraham and M. B. Visscher, J. gen. Physiol, 18, 695 (1935).

    Article  PubMed  CAS  Google Scholar 

  59. M. H. Jacobs, Cold Spr. Harb. Symp. quant. Biol, 8, 30 (1940).

    Article  CAS  Google Scholar 

  60. T. H. Wilson, Biochem. J., 56, 521 (1954).

    PubMed  CAS  Google Scholar 

  61. M. J. Jackson, R. J. Levin and E. J. Thompson, J. Physiol, 197, 16P (1968).

    PubMed  CAS  Google Scholar 

  62. R. J. C. Barry, S. Dikstein, J. Matthews, D. H. Smyth and E. M. Wright, J. Physiol, 171, 316 (1964).

    PubMed  CAS  Google Scholar 

  63. H. Newey and D. H. Smyth, Nature, 202, 400 (1964).

    Article  PubMed  CAS  Google Scholar 

  64. J. T. Hindmarsh, D. Kilby and G. Wiseman, J. Physiol, 186, 166 (1966).

    PubMed  CAS  Google Scholar 

  65. R. K. Crane, Protides Biol Fluids, 15, 227 (1967).

    Google Scholar 

  66. T. Z. Csaky and U. V. Lassen, Biochim. biophys. acta, 82, 245 (1964).

    Google Scholar 

  67. R. J. C. Barry, J. Eggenton and D. H. Smyth, J. Physiol, 204, 299 (1969).

    PubMed  CAS  Google Scholar 

  68. M. J. Jackson and D. H. Smyth, Nature, 219, 388 (1968).

    Article  PubMed  CAS  Google Scholar 

  69. M. J. Jackson, Ph.D. Thesis, University of Sheffield, 1966.

    Google Scholar 

  70. M. J. Jackson, Y-F. Shiau and M. M. Cassidy, Fed. Proc., 29, 595 (1970).

    Google Scholar 

  71. J. M. Dietschy and N. W. Carter, Science, 150, 1294 (1965).

    Article  PubMed  CAS  Google Scholar 

  72. M. J. Jackson, Y-F. Shiau and B. N. Morgan, Fed. Proc., 30, 538 (1971).

    Google Scholar 

  73. R. P. Spencer and K. R. Brody, Amer. J. Physiol, 206, 653 (1964).

    PubMed  CAS  Google Scholar 

  74. R. P. Spencer, K. R. Brody and F. Vishno, Comp. Biochem. Physiol, 17, 883 (1966).

    Article  PubMed  CAS  Google Scholar 

  75. D. S. Parsons and J. S. Prichard, Biochim. biophys. acta, 126, 471 (1966).

    Article  PubMed  CAS  Google Scholar 

  76. H. C. Tidwell and J. M. Johnston, Arch. Biochem. Biophys., 93, 546 (1961).

    Article  PubMed  CAS  Google Scholar 

  77. B. F. Martin, J. Anat., 90, 440 (1956).

    PubMed  CAS  Google Scholar 

  78. L. Biempica, O. Vilar and S. Gorodisch, Anat Rec., 139, 294 (1961).

    Google Scholar 

  79. D. Porte and C. Entenman, Amer. J. Physiol., 208, 607 (1965).

    PubMed  CAS  Google Scholar 

  80. C. A. M. Hogben, Fed. Proc., 13, 71 (1954).

    Google Scholar 

  81. C. A. M. Hogben, Electrolytes in Biological Systems, (A. M. Shanes, ed.), p. 176, American Physiological Society, Washington D.C. (1955).

    Google Scholar 

  82. C. A. M. Hogben, Circulation., 26, 1179 (1962).

    Article  PubMed  CAS  Google Scholar 

  83. C. E. Stevens, A. Dobson and J. H. Mammano, Amer. J. Physiol 216, 983 (1969).

    PubMed  CAS  Google Scholar 

  84. T. C. Butler, Science., 151, 1564 (1966).

    Article  PubMed  CAS  Google Scholar 

  85. E. M. Wright, J. Physiol 185, 486 (1966).

    PubMed  CAS  Google Scholar 

  86. J. Diamond, J, gen. Physiol 48, 15 (1964).

    Article  CAS  Google Scholar 

  87. M. Samijima, I. Sujimoto and I. Utsumi, J. Pharm. Soc. Jap., 88, 618 (1968).

    Google Scholar 

  88. H. D. Crone and T. E. B. Keen, Brit. J. Pharmacol., 35, 304 (1969).

    Article  CAS  Google Scholar 

  89. R. R. Levine, J. Pharmacol., 131, 328 (1961).

    CAS  Google Scholar 

  90. R. T. Whitlock and H. O. Wheeler, Amer. J. Physiol, 217, 310 (1969).

    PubMed  CAS  Google Scholar 

  91. E. E. Windhager, Micropuncture Techniques and Nephron Function, p. 193, Appleton-Century-Crofts, New York (1968).

    Google Scholar 

  92. T. H. Wilson and L. Kazyak, Biochim. biophys. acta, 24, 124 (1957).

    Article  PubMed  CAS  Google Scholar 

  93. L. A. Turnberg, J. S. Fordtran, N. W. Carter and F. C. Rector, J. Clin. Invest., 49, 548 (1970).

    Article  PubMed  CAS  Google Scholar 

  94. D. S. Parsons, Quart. J. Physiol, 41, 410 (1956).

    CAS  Google Scholar 

  95. K. A. Hubel, Amer. J. Physiol, 213, 1409 (1967).

    PubMed  CAS  Google Scholar 

  96. D. W. Powell, S. J. Malawer and G. R. Plotkin, Amer. J. Physiol, 215, 1226 (1968).

    PubMed  CAS  Google Scholar 

  97. H. H. Ussing, Acta Physiol scand., 17, 1 (1949).

    Article  PubMed  CAS  Google Scholar 

  98. A. K. Solomon, Transcellular Membrane Potentials and Ionic Fluxes, (F. M. Snell and W. K. Noell, eds.), p. 47, Gordon and Breach, New York (1964).

    Google Scholar 

  99. E. J. Conway, Physiol Rev., 37, 84 (1957).

    PubMed  CAS  Google Scholar 

  100. C. Lippe, A. Bianchi, D. Cremaschi and V. Capraro, Arch. int. Physiol Biochem., 73, 43 (1965).

    Article  CAS  Google Scholar 

  101. J. M. Diamond and W. H. Bossert, J. gen. Physiol, 50, 2061 (1967).

    Article  PubMed  CAS  Google Scholar 

  102. W. A. Brodsky and T. P. Shilb, Fed. Proc., 26, 1314 (1967).

    PubMed  CAS  Google Scholar 

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  1. Department of Physiology, George Washington University Medical Center, 1339 H Street, NW, Washington DC, 20005, USA

    Michael J. Jackson

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  1. Department of Physiology, The University, SI0 2TN, Sheffield, England

    D. H. Smyth

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Jackson, M.J. (1974). Transport of Short Chain Fatty Acids. In: Smyth, D.H. (eds) Intestinal Absorption. Biomembranes, vol 4B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3336-4_3

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  • DOI: https://doi.org/10.1007/978-1-4684-3336-4_3

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