Abstract
There is a complex and incomplete understanding of relationship between the immune system and malignancy. It is clear from many experimental systems that both cell-mediated immunity and the antibody-forming system can inhibit tumor development. There are also clinical data supporting such a host-protective function for immunity (3,6,12). However, the biological role of the immunological “surveillance” mechanisms in the development of spontaneous tumors remains to be determined (19). The surveillance concept was originally formulated with cell-mediated immunity in mind (24), however, it has become increasingly clear in the past years that the antibody forming system can also exert a powerful host-protective influence in vivo (9,15) and in vitro (8,17). The potential of the mononuclear phagocyte system alone, or in conjunction with other immunological defense mechanisms in tumor protection, is also well documented in these proceedings and elsewhere (5,10).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Alexander, P., Cancer Res., 34 (1974) 2082.
Baldwin, R.W., Bowen, J.G. and Price, M.R., Brit. J. Cancer, 28 (1973) 16.
Burnet, F.M., Immunological Surveillance, Pergamon Press, Oxford, (1970).
Cooper, M.D., Peterson, R.D.A., South, M.A. and Good, R.A., J. Exp. Med., 123 (1966) 75.
Evans, R., Cox, H. and Alexander, P., Proc. Soc. Exp. Med., 143 (1973) 259.
Good, R.A., Proc. Nat. Acad. Sci., 69 (1972) 1026.
Gorer, P.A. and Amos, D.B., Cancer Res., 16 (1956) 338.
Hayami, M., Hellstrom, I. and Hellstrom, K.E., Int. J. Cancer, 12 (1973) 667.
Hersey, P., Brit. J. Cancer, 28 (1973) 11.
Hibbs, J.B., Jr., Lambert, L.H., Jr. and Remington, J.S., Nature, 235 (1972) 48.
Kaliss, N., Cancer Res., 18 (1958) 992.
Klein, G., Immunological surveillance against neoplasia, Academic Press, New York, (1973–1974) 71.
Lam, K.M. and Linna, T.J., Fed. Proc., 34 (1975) 852.
Linna, T.J., Frommel, D. and Good, R.A., Int. Arch. Allergy, 42 (1972) 20.
Linna, T.J., Hu, C. and Thompson, K.D., J. Nat. Cancer Inst., 53 (1974) 847.
Morrison, D.F., Multivariate Statistical Methods, McGraw-Hill, New York, (1967).
Perlman, P., Perlman, H. and Wigzell, H., Transplant Rev., 13 (1973) 91.
Peterson, R.D.A., Burmester, B.R., Frederickson, T.N., Purchase, H.G. and Good, R.A., J. Nat. Cancer Inst., 32 (1964) 1343.
Prehn, R.T., J. Reticuloendothel. Soc. 10 (1971) 1.
Robinson, F.R. and Twiehaus, M.J., Avian Dis., 18 (1974) 278.
Svoboda, J., Nature, 186 (1960) 980.
Svoboda, J., Chyle, P., Simkovic, D. and Hilgert, I., Folia Biol., 9 (1963) 77.
Theilen, G.H., Zeigel, R.F. and Twiehaus, M.J., J. Nat. Cancer Inst., 37 (1966) 731.
Thomas, L., Cellular and humoral aspects of hypersensitive states, (Ed. H.S. Lawrence), Hoeber-Harper, New York, (1959) 529.
Thompson, K.D. and Linna, T.J., Nature, 245 (1973) 10.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Linna, T.J., Hu, C., Lam, K.M. (1976). Host Protection by Cell-Mediated and by Humoral Immunity in Malignancy. In: Friedman, H., Escobar, M.R., Reichard, S.M. (eds) The Reticuloendothelial System in Health and Disease. Advances in Experimental Medicine and Biology, vol 73B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3300-5_32
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3300-5_32
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3302-9
Online ISBN: 978-1-4684-3300-5
eBook Packages: Springer Book Archive