Abstract
The immune system has remarkable ability to distinguish self from non-self. Autoimmune diseases represent exceptions to the general rule of self-recognition. Their study provides clues about the basis of the rule. In most human autoimmune diseases of solid tissues, one sees infiltration by macrophages, plasma cells and eosinophils in addition to large numbers of lymphocytes. Autoimmune lesions may be the result of damage initiated by autoantibodies, by lymphocytes sensitized to self-antigen, by activated macrophages, or by the two or more of these factors combined.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bigazzi, P.E. and Rose, N.R., Prog. in Allergy, (1975) 245.
Bucsi, R.A. and Straussen, H.R., Experientia, 28 (1972) 194.
Clagett, J., Wilson, C. and Weigle, W.O., J. Exp. Med., 140 (1974) 1439.
Glover, E.L. and Reuber, M.D., Endocrinology, 80 (1967) 361.
Glover, E.L. and Reuber, M.D., Arch. Path., 86 (1968) 542.
Glover, E.L., Reuber, M.D. and Godfrey, E.F., Arch. Environm. H1th., 18 (1969) 901.
Hajdu, A. and Rona, G., Experientia, 25 (1969) 1325.
McMaster, P.R.B., Lerner, E.M. and Exum, E., J. Exp. Med., 113 (1961) 611.
McMaster, P.R.B. and Lerner, E.M., J. Immunol., 99 (1967) 208.
Nakamura, R. and Weigle, W.O., Int. Arch. Allergy, 32 (1967) 506.
Nakamura, R.M. and Weigle, W.O., J. Exp. Med., 130 (1969) 263.
Penhale, W.J., Farmer, A., McKenna, R.P. and Irvine, W., Clin. Exp. Med., 15 (1973) 225.
Reuber, M.D., Arch. Environmn. H1th., 21 (1970) 734.
Ringertz, B., Wasserman, J., Packalen, Th. and Perlmann, P., Int. Arch. Allergy, 40 (1971) 917.
Rose, N.R., Ann. N.Y. Acad. Sci., 249 (1975a) 116.
Rose, N.R., Cellular Immunol., 18 (1975b) 360.
Rose, N.R. and Kite, J.H., In: Int. Convoc. on Immunol. (Eds. Rose and Milgrom) S. Karger, Basel, Switzerland, (1969) 247.
Rose, N.R. Seminars in Thrombosis & Hemostasis 1 (1975) 319.
Rose, N.R., In: Textbook of Immunopathology, (Eds. Miescher and Muller-Eberhard) Grune and Stratton, Inc., New York, New York (1976)
Silverman, D. and Rose, N.R., Proc. Soc. Exp. Biol. Med., 138 (1971) 579.
Silverman, D. and Rose, N.R., Science, 184 (1974a) 162.
Silverman, D. and Rose, N.R., J. Nat. Cancer Inst., 53 (1974b) 1721.
Silverman, D. and Rose, N.R., J. Immunol., 114 (1975) 145.
Snell, K.C., In: The Pathology of Laboratory Animals, (Eds. Ribelin and McCoy) Charles C. Thomas, Springfield, Illinois (1971) 241.
Talal, N., Dauphinee, M., Pillafisetty, R. and Goldblum, R., Ann. N.Y. Acad. Sci., 249 (1975) 438.
Tomazic, V. and Rose, N.R., Clin. Immunol, and Immunopathol., 4 (1975) 511
Tomazic, V., Rose, N.R. and Shreffler, D.C., J. Immunol., 112 (1974) 965.
Twarog, F.J. and Rose, N.R., J. Immunol., 104 (1970) 1467.
Vladutiu, A.O. and Rose, N.R., J. Immunol., 106 (1971) 1139.
Welch, P. and Kite, J.H., Fed. Proc, 30 (1971) 306.
Wick, G., Kite, J.H., Cole, R.K. and Witebsky, E., J. Immunol., 104 (1970) 45.
Wick, G., Sundick, R.S. and Albini, B., Clin. Immunol. Immuno-path., 3 (1974) 272.
Witebsky, E., Kite, J., Wick, G. and Cole, R.K., J. Immunol., 103 (1969) 708.
Yamada, S., Masuko, K., Ito, M. and Nagayo, T., Gann. 64 (1973) 287.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Rose, N.R., Bigazzi, P.E., Noble, B. (1976). Spontaneous Autoimmune Thyroiditis in the BUF Rat. In: Friedman, H., Escobar, M.R., Reichard, S.M. (eds) The Reticuloendothelial System in Health and Disease. Advances in Experimental Medicine and Biology, vol 73B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3300-5_18
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3300-5_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3302-9
Online ISBN: 978-1-4684-3300-5
eBook Packages: Springer Book Archive