The Reticuloendothelial System (Res) in Experimental Amebic Meningoencephalitis

  • A. J. Martinez
  • J. Astruc
  • M. Escobar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)


Nelson,et al. (18,19) in their study of experimental bacterial meningitis due to Escherichia coli reported that the pial and adventitial cells (pericytes) became phagocytic while the arachnoidal cells were less active in phagocytosis and did not ingest bacteria. Morgan, et al. (16) demonstrated in aseptic leptomeningitis that pial and arachnoidal cells became phagocytic and they suggested that these mesenchymal cells, like RES cells, were capable of responding to a variety of stimuli changing their function and morphology. Rio-Hortega (21–23) demonstrated that the micro-glial cells in the brain and similar cells of extracerebral sites have argentophilic cytoplasm and cytoplasmic processes. However, they are neither phagocytic nor stainable with vital dyes as other cells of the RES until altered or stimulated by an inflammatory reaction. The latter elicits its protective functions by modifying their physiological activity. Microglia (Hortega cells),“gitterzellen”, or lipophages can be transformed into phagocytic cells or free macrophages during injury, trauma or infectious processes (3,15,16,21,23,25).


Bacterial Meningitis Aseptic Meningitis Cytoplasmic Process Osmic Acid Sustentacular Cell 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • A. J. Martinez
    • 1
  • J. Astruc
    • 1
  • M. Escobar
    • 1
  1. 1.Medical College of VirginiaRichmondUSA

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