Chemotaxis of Polymorphonuclear Neutrophilic Leukocytes by Mannan-Enriched Preparations of Candida Albicans

  • B. A. Weeks
  • M. R. Escobar
  • P. B. Hamilton
  • V. M. Fueston
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)


Chemotaxis is the directional migration of cells in response to a chemical stimulus. This phenomenon appears to be responsible for the accumulation of leukocytes during inflammation. Although there are many reports in the literature regarding chemotaxis of polymorphonuclear neutrophilic leukocytes (PMN) using bacteria in vitro (3), little is known about it when stimulation is produced by Candida albicans. This microorganism is responsible for more opportunistic infections than any other fungal species (5). Yet, the clinical diagnosis and the laboratory confirmation of systemic can-didiasis are often difficult to establish because of the lack of pathognomonic signs before death as well as the lack of specificity of results obtained in the laboratory.


Candida Albicans Chemotactic Activity Chemotaxis Assay Cell Wall Fraction Avirulent Strain 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • B. A. Weeks
    • 1
  • M. R. Escobar
    • 2
  • P. B. Hamilton
    • 3
  • V. M. Fueston
    • 1
  1. 1.Old Dominion UniversityNorfolkUSA
  2. 2.Medical College of VirginiaRichmondUSA
  3. 3.North Carolina State UniversityRaleighUSA

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