The NADPH Oxidase Activity of Polymorphonuclear Neutrophilic Leukocytes Revisited

  • P. Patriarca
  • P. Dri
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)


The direct oxidation of NADPH by an activated NADPH oxidase was proposed several years ago by our laboratory (12,14,17) as the primary event of the metabolic stimulation in phagocytosing leukocytes that consists of increased oxygen uptake, increased production of hydrogen peroxide and superoxide anion, and increased activity of the hexose monophosphate shunt (1,3,4,5,6,15). The characteristics of the oxidase have been further investigated in our laboratory and the results of these studies are reported in the present paper.


NADPH Oxidase NADPH Oxidase Activity NADPH Oxidation Guanidinium Chloride NADPH Concentration 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • P. Patriarca
    • 1
  • P. Dri
    • 1
  1. 1.Istituto di Patologia GeneraleTriesteItaly

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