Biochemical Aspects of the Function of the Reticulo-Endothelial System

  • M. L. Karnovsky
  • D. Drath
  • J. Lazdins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 73)


The title of this presentation was assigned, and it is truly doubtful whether we can present a picture that is consistent with the assignment. The reasons for this are manifold. First, the reticulo-endothelial system per se, as it was defined by Aschoff (1) is a broader group of cells than we are competent to discuss. Indeed, we find ourselves much more comfortable with the concept of the “mononuclear phagocyte system” proposed at the conference on Mononuclear Phagocytes in Leiden, 1969 (18). The system, as described there, is concerned with mononuclear phagocytes, a group of cells that are related in morphology, functions and origin, ranging from the promonocytes through the monocytes of the blood to the macrophages of the tissues, including histiocytes, Kupffer cells, the alveolar macrophages; macrophages of the spleen, lymph nodes, bone marrow, peritoneum and bone tissue; and the microglia of the nervous system. Obviously there is overlap between the two classifications. What we shall have to say in this report will focus largely on the macrophage as it is obtained by simple lavage from the peritoneal cavity; from the peritoneal cavity after elicitation with an agent such as caseinate; or as it is washed out of the alveoli. It is not that biochemical studies have not been performed on other cells of this system--there have been such studies, e.g., on the Kupffer cells of the liver, but these studies are relatively few and perhaps more difficult to interpret than experiments on defined cell populations.


Alveolar Macrophage Peritoneal Macrophage H202 Production Mononuclear Phagocyte Mononuclear Phagocyte System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Aschoff, L., Ergeb. Inn. Med. und Kindersheilk, 26 (1924) 1.Google Scholar
  2. 2.
    Babior, B.M., Kipnes, R.S. and Curnutte, J.T., J. Clin. Invest., 52 (1973) 741.PubMedCrossRefGoogle Scholar
  3. 3.
    Becker, E.L. and Ward, P.A., J. Exp. Med., 129 (1969) 569.PubMedCrossRefGoogle Scholar
  4. 4.
    Briggs, R.T., Drath, D.B., Karnovsky, M.L. and Karnovsky, M.J., J. Cell Biol., in press.Google Scholar
  5. 5.
    Briggs, R.T., Karnovsky, M.L. and Karnovsky, M.J., J. Cell Biol., 64 (1975) 254.PubMedCrossRefGoogle Scholar
  6. 6.
    Curnutte, J.T., Karnovsky, M.L. and Babior, B.M., Clin. Res., 23 (1975) 271a.Google Scholar
  7. 7.
    DePierre, J. and Karnovsky, M.L., J. Biol. Chem., 249 (1974) 7111, 7121.PubMedGoogle Scholar
  8. 8.
    Drath, D. and Karnovsky, M.L., J. Exp. Med., 141 (1975) 257.PubMedCrossRefGoogle Scholar
  9. 9.
    Evans, W.H. and Karnovsky, M.L., Biochemistry, 1 (1962) 159.PubMedCrossRefGoogle Scholar
  10. 10.
    Johnston, R.B., Keele, B.B., Misra, H.P., Lehmeyer, J.E., Webb, L.S., Baehner, R.L. and Rajagopalan, K.V., J. Clin. Invest., 55 (1975) 1357.Google Scholar
  11. 11.
    Karnovsky, M.L., Frog. in Immunology II (Ed. L. Brent and J. Holborow), North-Holland Pub. Co., 4 (1974) 423.Google Scholar
  12. 12.
    Karnovsky, M.L., Lazdins, J., Drath, D. and Harper, A., Ann. NY Acad. Sci., 256 (1975) 266.PubMedCrossRefGoogle Scholar
  13. 13.
    Karnovsky, M.L., Simmons, S., Glass, E.A., Shafer, A.W. and Hart, P. D’Arcy, Mononuclear Phagocytes (Ed. R. van Furth ), Blackwell, Oxford (1970) 103.Google Scholar
  14. 14.
    Klebanoff, S.J., J. Exp. Med., 126 (1967) 1063.Google Scholar
  15. 15.
    Klebanoff, S.J., Science, 169 (1970) 1097.CrossRefGoogle Scholar
  16. 16.
    Klebanoff, S.J., Ann. Rev. Med., 22 (1971) 39.PubMedCrossRefGoogle Scholar
  17. 17.
    Klebanoff, S.J., J. Biol. Chem., 249 (1974) 3724.PubMedGoogle Scholar
  18. 18.
    Langevoort, H.L, Cohn, Z.A., Hirsch, J.G., Humphrey, J.H., Spector, W.G. and van Furth, R., Mononuclear Phagocytes (Ed. R. van Furth ), Blackwell, Oxford (1970).Google Scholar
  19. 19.
    Lehrer, R.I. and Cline, M.J., J. Clin. Invest., 48 (1969) 1478.Google Scholar
  20. 20.
    Mackaness, G.B., J. Exp. Med., 120 (1964) 105.PubMedCrossRefGoogle Scholar
  21. 21.
    Patriarca, P., Dri, P., Kakinuma, K., Tedesco, F. and Rossi, F., Biochim. Biophys. Acta, 385 (1975) 380.CrossRefGoogle Scholar
  22. 22.
    Patriarca, P., Dri, P. and Rossi, F., FEBS Letters, 43 (1974) 247.PubMedCrossRefGoogle Scholar
  23. 23.
    Ratzan, K.R., Mosher, D.M., Keusch, G.T. and Weinstein, L., Infect. Immunol., 5 (1972) 499.Google Scholar
  24. 24.
    Romeo, D., Cramer, R., Marzi, T., Soranzo, M.R., Zabucchi, G. and Rossi, F., J. Reticuloendothel. Soc., 13 (1973) 399.PubMedGoogle Scholar
  25. 25.
    Root, R.K., Metcalf, J., Oshino, N. and Chance, B., J. Clin. Invest., 55 (1975) 945.PubMedCrossRefGoogle Scholar
  26. 26.
    Salin, M.L. and McCord, J.M., J. Clin. Invest., 54 (1974) 1005.Google Scholar
  27. 27.
    Simmons, S.R. and Karnovsky, M.L., J. Exp. Med., 138 (1973) 44.PubMedCrossRefGoogle Scholar
  28. 28.
    Stubbs, M., Kühner, A.V., Glass, E.A., David, J.R. and Karnovsky, M.L., J. Exp. Med., 137 (1973) 537.PubMedCrossRefGoogle Scholar
  29. 29.
    Takanaka, K. and O’Brien, P.J., Arch. Biochem. Biophys., 169 (1975) 428, 436.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. L. Karnovsky
    • 1
  • D. Drath
    • 1
  • J. Lazdins
    • 1
  1. 1.Harvard Medical SchoolBostonUSA

Personalised recommendations