Abstract
The exact mechanism as how cerebral vessels are dilated and CBF increases during arterial hypoxia and epileptic Scizures is still poorly understood (Kuschinsky and Wahl, 1978; Winn et al., 1981a; Dora, 1984a). Because recently it was suggested that adenosine may fulfill a critical role in the regulation of CBF (Winn et al,, 1981a), and Jöbsis (1977) postulated cytochrome oxidase as being responsible for the dilatation of cerebral vessels during hypoxia, the present study was devoted to get further data on these issues.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Astrup, J., Heuser, D.J., Lassen, N.A., Nilsson, B., Norberg, K., Siesjö, B.K., 1978, Evidence against H+ and K+ as main factors for the control of cerebral blood flow, in: Cerebral Vascular Smooth Muscle and its Control, Ciba Foundation Symposium 56, new series pp. 313–332, Elsevier, Amsterdam.
Dora, E., 1984a, A simple cranial window technique for optical monitoring of cerebrocortical microcirculation and NAD/NADH redox state. Effect of mitochondrial electron transport inhibitors and anoxic anoxia. J. Neurochem. 42:101–108.
Dora, E., 1984b, Further studies on the reflectometric method used for monitoring of cerebrocortical microcirculation. Importance of lactate anions, per se, in the coupling between cerebral blood flow and metabolism. Acta Physiol. Hung. in press.
Dora, E., Koller, A., Kovách, A.G.B., 1984, Effect of topical adenosine deaminase treatment on the functional hyperemic and hypoxic responses of cerebrocortical microcirculation. J. Cereb. Blood Flow Metabol., 4:447–457.
Eke, A., Hutiray, Gy., Koväch, A.G.B., 1979, Induced hemodilution detected by reflectometry for measuring microregional blood flow and blood volume in cat brain cortex. Am. J. Physiol., 236:H759–768.
Emerson, T.E., Raymond, R.M., 1981, Involvement of adenosine in cerebral hypoxic hyperemia in dog. Am.J. Physiol. 241:H134–138.
Jöbsis, F.F., 1977, What is a molecular oxygen sensor? What is a transduction process?, in: Tissue Hypoxia and Ischmia, M. Reivich, R. Coburn, S. Lahiri, B. Chance, eds., pp. 3–17, Plenum Press, New York.
Kovách, A.G.B., Dora, E., Szedlacsek, S., Koller, A., 1983, Effect of the organic calcium antagonist D-600 on cerebrocortical vascular and redox responses evoked by adenosine, anoxia, and epilepsy. J. Cereb. Blood Flow Metabol., 3:51–61.
Kuschinsky, W., Wahl, M., 1978, Local chemical and neurogenic regulation of cerebral vascular resistance. Physio1. Rev., 58:656–689.
Leniger-Follert, E., 1984, Mechanisms of regulation of cerebral microflow during bicuculline-induced Scizures in anaesthetized cats. J. Cereb. Blood Flow Metabol., 4:150–165.
Morii, S., Winn, H.R., Berne, R.M., 1983, Effect of theophylline, an adenosine receptor blocker, on cerebral blood flow (CBF) during rest and transient hypoxia. J. Cereb. Blood Flow Metabol., 3, suppl. 1:S480.
Nilsson, B., Rehncrona, S., Siesjö, B.K., 1978, Coupling of cerebral metabolism and blood flow in epileptic Scizures, hypoxia, and hypoglycemia, in: Cerebral Vascular Smooth Muscle and its Control, Ciba Foundation Symposium 56, new series, pp 199–214, Elsevier, Amsterdam.
Rehncrona, S., Siesjö, B.K., Westerberg, E., 1978, Adenosine and cyclic AMP in cerebral cortex of rats in hypoxia, status epilepticus and hypercapnia. Acta Physiol. Scand., 104:453–463.
Wahl, M., Kuschinsky, W., 1976, The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline. Pflügers Arch., 362:55–59.
Wahl, M., Kuschinsky, W., 1977, Influence of H+ and K+ on adenosine induced dilatation at pial arteries of cats. Blood Vess., 14: 285–293.
Winn, H.R., Rubio, G.R., Berne, R.M., 1981a, The role of adenosine in the regulation of cerebral blood flow. J. Cereb. Blood Flow Metabol., 1:239–244.
Winn, H.R., Rubio, R., Curnish, R.R., Berne, R.M., 1981b, Changes in regional cerebral blood flow (rCBF) caused by increases in CSF concentrations of adenosine and 2-chloroadenosine (CHL-ADO). J. Cereb. Blood Flow Metabol., 1,suppl. 1:S401.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Dóra, E., Kovách, A.G.B. (1985). Regulation of Cerebral Blood Flow (CBF) during Hypoxia and Epileptic Seizures. In: Kreuzer, F., Cain, S.M., Turek, Z., Goldstick, T.K. (eds) Oxygen Transport to Tissue VII. Advances in Experimental Medicine and Biology, vol 191. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3291-6_8
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3291-6_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3293-0
Online ISBN: 978-1-4684-3291-6
eBook Packages: Springer Book Archive