Abstract
The effects of various compounds on the transport of uric acid by rabbit kidney have been investigated in several previous studies. Experiments utilizing clearance techniques have established that uric acid clearance is reduced by probenecid, salicylate, PAH, chlorothiazide and a number of other compounds (1,2). Stop-flow analysis has indicated that probenecid reduces uric acid clearance by blocking its secretion in the proximal tubule (3).
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References
Poulsen, H.: Inhibition of uric acid excretion in rabbits given probenecid or salicylic acid. Acta Pharmacol. Toxicol. 11:277–286, 1955.
Høller, J.V.: Clearance experiments on the effect of probenecid on urate excretion in the rabbit. Acta Pharmacol. Toxicol. 23:321–328, 1965.
Beechwood, E.C., Berndt, W.O. and Mudge, G.H.: Stop-flow analysis of tubular transport of uric acid in rabbits. Am. J. Physiol. 207:1265–1272, 1964.
Platts, M.M. and Mudge, G.H.: Accumulation of uric acid by slices of kidney cortex. Am. J. Physiol. 200:387–391, 1961.
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© 1977 Plenum Press, New York
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Kippen, I., Klinenberg, J.R. (1977). Effects of Drugs on the Uptake of Uric Acid by Separated Renal Tubules of the Rabbit. In: Müller, M.M., Kaiser, E., Seegmiller, J.E. (eds) Purine Metabolism in Man—II. Advances in Experimental Medicine and Biology, vol 76B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3285-5_16
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DOI: https://doi.org/10.1007/978-1-4684-3285-5_16
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