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Factors Affecting Urate Reabsorption in the Rat Kidney

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Purine Metabolism in Man—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 76B))

Abstract

Urate handling in the rat kidney has been shown to involve bidirectional transport in the proximal tubule, net reabsorption in the loops of Henle and negligible transport in the distal nephron. In this paper, results will be discussed describing the effects of luminal urate concentration, pH and flow rate on urate reabsorption.

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References

  1. Berliner, R.W., Hilton, J.G., Yü, T.F., and Kennedy, T.J.: The renal mechanism for urate excretion in man. J.Clin.Invest. 29:396, 1950.

    Article  PubMed  CAS  Google Scholar 

  2. Cannon, P.J., Symchych, P.S., and Demartini, F.E.: The distribution of urate in human and primate kidney. Proc.Soc.Exptl.Biol.Med. 129:278, 1968.

    CAS  Google Scholar 

  3. Cannon, P.J., Svahn, D.S., and Demartini, F.E.: The influence of hypertonic saline infusions upon the fractional reabsorption of urate and other ions in normal and hypertensive man. Circulation 41:97, 1970.

    Article  PubMed  CAS  Google Scholar 

  4. Diamond, H.S. and Meisel, A.: Influence of volume expansion, serum sodium and fractional excretion of sodium on urate excretion. Pflügers Arch. 356:47, 1975.

    Article  PubMed  CAS  Google Scholar 

  5. Epstein, F.H. and Pigeon, G.: Experimental urate nephropathy. Studies of the distribution of urate in renal tissue. Nephron 1:144, 1964.

    Article  PubMed  CAS  Google Scholar 

  6. Fanelli, G.M., Bohn, D.L., and Stafford, S.: Functional characteristics of renal urate transport in the cebus monkey. Am.J.Physiol. 218:627, 1970.

    PubMed  CAS  Google Scholar 

  7. Friedmann, M. and Byers, S.O.: Distribution of uric acid in rat tissues and its production in tissue homogenates. Am.J. Physiol. 172:29, 1953.

    Google Scholar 

  8. Greger, R., Lang, F., Puls, F., Deetjen, P.: Urate interaction with plasma proteins and erythrocytes. Pflügers Arch. 352, 121 (1974).

    Article  PubMed  CAS  Google Scholar 

  9. Greger, R., Lang, F., and Deetjen, P.: Urate handling by the rat kidney. IV. Reabsorption in the loops of Henle. Pflügers Arch. 352:115, 1974.

    Article  PubMed  CAS  Google Scholar 

  10. Gutman, A.B., Yü, T.F. and Sirota, J.H.: Contrasting effects of HCO3 and diamox with equivalent alkalization of urine on salicylate uricosuria in man.Fed.Proc. 15:85, 1956.

    Google Scholar 

  11. Hierholzer, K., Mueller-Suur, R., Gutsche, H.U., Butz, M., and Lichtenstein, I.: Filtration in surface glomeruli as regulated by flow rate through the loop of Henle. Pflügers Arch. 352:315, 1974.

    Article  PubMed  CAS  Google Scholar 

  12. Isomaeki, H. and Kreus, K.E.: Serum uric acid in respiratory acidosis. Acta Med.Scand. 184:293, 1968.

    Article  Google Scholar 

  13. Kramp, R.A., Lassiter, W.E., and Gottschalk, C.W.: Urate-2 14C transport in the rat nephron. J.Clin.Invest. 50:35, 1971

    Article  PubMed  CAS  Google Scholar 

  14. Lang, F., Greger, R., and Deetjen, P.: In vivo studies on uricase activity in the rat. Pflügers Arch. 351:323, 1974.

    Article  PubMed  CAS  Google Scholar 

  15. Lang, F.: Parameters and mechanisms of urate transport in the rat kidney. Intern.Symp.on amino acid and uric acid. Innsbruck, 1975. Ed.: S. Silbernagl, F. Lang, R. Greger. Thieme Stuttgart, New York

    Google Scholar 

  16. Lang, F., Greger, R., Deetjen, P.: Effect of diuretics on uric acid metabolism and excretion. Intern.Symp.on diuretics in research and clinics. Buergenstock 1975. Ed.:W. Siegenthaler. Thieme, Stuttgart, New York.

    Google Scholar 

  17. Lecocq, F.R. and McPhaul, J.J., Jr.: The effects of starvation, high fat diets and ketone infusions on uric acid balance. Metabolism 14:186, 1965.

    Article  PubMed  CAS  Google Scholar 

  18. Manuel, M.A. and Steele, T.H.: Pyrazinamide suppression of the uricosuric response to sodium chloride infusion. J.Lab.Clin.Med. 83, 417, 1974.

    PubMed  CAS  Google Scholar 

  19. Michael, S.T.: The relation of uric acid excretion to blood lactic acid in man. Am.J.Physiol. 141:71, 1944.

    CAS  Google Scholar 

  20. Moller, J.V.: The effects of D- and L- lactate and osmotic diuretics on uric acid clearance in the rabbit. Acta Physiol. Scand. 54:30, 1962.

    Article  PubMed  CAS  Google Scholar 

  21. Musil, J. and Granzer, E.: Purine metabolism during experimental disturbances of the homeostasis (Abstr.). Experientia 30:6, 681, 1974.

    Google Scholar 

  22. Nolan, R.P. and Foulkes, E.C.: Studies on renal urate secretion in the dog. J.Pharmacol.Exptl. Therap. 179:429, 1971.

    CAS  Google Scholar 

  23. Nugent, C.A.: Renal urate excretion in gout studied by feeding ribonucleic acid. Arthr.& Rheum. 8:671, 1965.

    Article  CAS  Google Scholar 

  24. Reem, G.H. and Vanamee, P.: Effect of sodium lactate on urate clearance in the dalmatian and in the mongrel. Am.J. Physiol. 207:113, 1964.

    PubMed  CAS  Google Scholar 

  25. Roch-Ramel, F., Diezi-Chomety, F., de Rougemont, D., Tellier, M., Widmer, J., Peters, G.: Renal excretion of uric acid in the rat: a micropuncture and microperfusion study. Am.J.Physiol. 230:768 (1976).

    PubMed  CAS  Google Scholar 

  26. Skeith, M.D. and Healey, L.A.: Urate clearance in cebus monkeys, Am.J.Physiol. 214:582, 1968.

    PubMed  CAS  Google Scholar 

  27. Sonnenberg, H., Oelert, H., and Baumann, K.: Proximal tubular reabsorption of some organic acids in the rat kidney in vivo. Pflügers Arch. 286:171, 1965.

    Article  CAS  Google Scholar 

  28. Steele, T.H. and Oppenheimer, S.: Factors affecting urate excretion following diuretic administration in man. Am.J.Med. 47:564, 1969.

    Article  PubMed  CAS  Google Scholar 

  29. Steele, T.H.: Evidence for altered renal urate reabsorption during changes in volume of the extracellular fluid. J.Lab.Clin.Med. 74:288, 1969.

    PubMed  CAS  Google Scholar 

  30. Steele, T.H.: Pyrazinamide suppressiblity of urate excretion in health and disease. International symposium on amino acid transport and uric acid. Ed.: Silbernagl, S., Lang, F., Greger, R. Georg Thieme Verlag, Stuttgart, 1975.

    Google Scholar 

  31. Weinman, E.J., Eknoyan, G., and Suki, W.N.: The influence of the extracellular fluid volume on the tubular reabsorption of uric acid. J.Clin.Invest. 55:283, 1975.

    Article  PubMed  CAS  Google Scholar 

  32. Yü, T.F., Sirota, J.H., Berger, L., Halpern, M., and Gutman, A.B.: Effect of sodium lactate infusion on urate clearance in man. Proc. Soc. Exp. Biol. Med. 96:809, 1957.

    PubMed  Google Scholar 

  33. Yü, T.F., Berger, L., and Gutman, A.B.: Renal function in gout. Effect of uric acid loading on renal excretion of uric acid. Am. J. Med. 33:829, 1962.

    Article  PubMed  Google Scholar 

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© 1977 Plenum Press, New York

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Lang, F., Greger, R., Deetjen, P., Knox, F.G. (1977). Factors Affecting Urate Reabsorption in the Rat Kidney. In: Müller, M.M., Kaiser, E., Seegmiller, J.E. (eds) Purine Metabolism in Man—II. Advances in Experimental Medicine and Biology, vol 76B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3285-5_14

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  • DOI: https://doi.org/10.1007/978-1-4684-3285-5_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3287-9

  • Online ISBN: 978-1-4684-3285-5

  • eBook Packages: Springer Book Archive

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