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Saturated and Mono-Unsaturated Fatty Acid Biosynthesis in Brain: Relation to Development in Normal and Dysmyelinating Mutant Mice

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Function and Biosynthesis of Lipids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 83))

Abstract

Fatty acids, constituents of most lipids, play a key role in membrane structure and function. Very long chain fatty acids, either saturated or mono-unsaturated are necessary to myelin; therefore, their biosynthesis is fundamental for normal brain maturation. Identification of some of the biosynthetic pathways has been facilitated by the use of mutant mice (Quaking and Jimpy) characterized by a defective myelination (1) and deficient in very long chain fatty acids (2, 3).

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Authors and Affiliations

  1. Laboratoire de Neurochimie, Hôpital de la Salpêtrière, Inserm U. 134, 75634, Paris Cédex 13, France

    J. M. Bourre, S. Pollet, M. Paturneau-Jouas & N. Baumann

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  1. J. M. Bourre
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  2. S. Pollet
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  3. M. Paturneau-Jouas
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  4. N. Baumann
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Editor information

Editors and Affiliations

  1. Universidad Nacional del Sur — CONICET, Bahía Blanca, Argentina

    Nicolás G. Bazán  & Norma M. Giusto  & 

  2. Universidad Nacional de La Plata, La Plata, Argentina

    Rodolfo R. Brenner

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© 1977 Plenum Press, New York

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Bourre, J.M., Pollet, S., Paturneau-Jouas, M., Baumann, N. (1977). Saturated and Mono-Unsaturated Fatty Acid Biosynthesis in Brain: Relation to Development in Normal and Dysmyelinating Mutant Mice. In: Bazán, N.G., Brenner, R.R., Giusto, N.M. (eds) Function and Biosynthesis of Lipids. Advances in Experimental Medicine and Biology, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3276-3_9

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  • DOI: https://doi.org/10.1007/978-1-4684-3276-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3278-7

  • Online ISBN: 978-1-4684-3276-3

  • eBook Packages: Springer Book Archive

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