Abstract
The adult brain contains high levels of polyenoic fatty acids deriving from linoleic (18:2 Δ9,12 n — 6) and from linolenic acid (18:3 Δ9,12,15 n — 3). The two major polyunsaturated fatty acids (Pufa) present in brain are arachidonic acid (20:4 Δ5,8,11,14) of the linoleic acid series and especially docosahexaenoic acid (22:6 Δ4,7,10,13,16,19) of the linolenic acid series. The higher levels of 22:6 in brain, in comparison with other tissues, suggest a special function of the n-3 fatty acid family in nervous system. It has been recently found, for instance, that the electrical response of rod outer segments in the retina to illumination is affected by dietary induced changes of 22:6 n-3 levels in this tissue (Wheeler et al., 1970).
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Galli, C. et al. (1977). Dietary Essential Fatty Acids, Brain Polyunsaturated Fatty Acids, and Prostaglandin Biosynthesis. In: Bazán, N.G., Brenner, R.R., Giusto, N.M. (eds) Function and Biosynthesis of Lipids. Advances in Experimental Medicine and Biology, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3276-3_51
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DOI: https://doi.org/10.1007/978-1-4684-3276-3_51
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