Abstract
Fundamental understanding of the oxygen level in microvasculature and tissues of developing tumors may be of great import in elucidation of observed radioresistance and decreased radiation sensitivity of certain tumors in humans. Frequently radiation therapy which at certain doses causes death of cells in vitro fails to kill the cells in vivo, even though the doses are comparable. L. H. Gray, et al, 1953, demonstrated reduced radiation sensitivity of cells which are oxygen deficient. Therefore, this study was undertaken to demonstrate whether changes in microvasculature and microcirculation play a significant role in the oxygen deficiency of various portions of a tumor in vivo.
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References
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© 1976 Plenum Press, New York
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Puffer, H.W., Warner, N.E., Schaeffer, L.D., Wetts, R.W., Bradbury, M. (1976). Preliminary Observations of Oxygen Levels in Microcirculation of Tumors in C3H Mice. In: Grote, J., Reneau, D., Thews, G. (eds) Oxygen Transport to Tissue — II. Advances in Experimental Medicine and Biology, vol 75. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3273-2_71
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DOI: https://doi.org/10.1007/978-1-4684-3273-2_71
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3275-6
Online ISBN: 978-1-4684-3273-2
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