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Oxygen Transport to Tissue — II pp 241–249Cite as

A Theoretical Model of the Respiratory Function of Blood

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 75))

Abstract

The physiology and pathophysiology of oxygen transport as mediated by changes in erythrocyte acid-base status and organic phosphate content have been subjects of intense research activity in recent years. These endeavors have been inspired by the discovery of the dramatic effect of changes in red cell 2,3 diphosphoglycerate (DPG) concentration upon hemoglobin oxygen affinity (3,4), and such clinical observations as the inverse relationship between the amounts of DPG and hemoglobin in the blood of anemic patients (5,9). However, in the face of insufficient as well as conflicting data, the significance of changes in the oxygen affinity of hemoglobin as an adaptive mechanism for the maintenance of sufficient oxygen supply remains a matter of speculation (see, for example, the reviews of Bellingham, Rørth, and Woodson in ref. 6).

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References

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Author information

Authors and Affiliations

  1. Department of Physiology, Odense University, Odense, Denmark

    J. H. Meldon & L. Garby

Authors
  1. J. H. Meldon
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  2. L. Garby
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Editor information

Editors and Affiliations

  1. University of Mainz, Mainz, West Germany

    Jürgen Grote  & Gerhard Thews  & 

  2. Louisiana Tech University, Ruston, Louisiana, USA

    Daniel Reneau

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© 1976 Plenum Press, New York

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Meldon, J.H., Garby, L. (1976). A Theoretical Model of the Respiratory Function of Blood. In: Grote, J., Reneau, D., Thews, G. (eds) Oxygen Transport to Tissue — II. Advances in Experimental Medicine and Biology, vol 75. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3273-2_30

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  • DOI: https://doi.org/10.1007/978-1-4684-3273-2_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3275-6

  • Online ISBN: 978-1-4684-3273-2

  • eBook Packages: Springer Book Archive

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