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Iron and Copper Proteins pp 103–117Cite as

Some Properties of Bovine Pineal Tryptophan Hydroxylase

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 74))

Abstract

The conversion of L-tryptophan to L-5HTP is the first step in the biosynthesis of serotonin in the brain and of melatonin in the pineal gland and is catalyzed by tryptophan hydroxylase. Since the first demonstration by Grahame-Smith that a specific tryptophan hydroxylase exists in the brain (1), the enzyme has been studied at various laboratories including our own (2–11) and is now accepted as a pterin-dependent aromatic amino acid monooxygenase (12).

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Abbreviations

5HTP:

5-hydroxytryptophan

BpH4 :

5,6,7,8-tetrahydrobiopterin

DMPH4 :

6,7-dimethyl-5,6,7,8-tetra-hydropterin

6MPH4 :

6-methyl-5,6,7,8-tetrahydropterin

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Hamamatsu University School of Medicine, Handa-cho, Hamamatsu-shi, 431-31, Japan

    Arata Ichiyama & Hiroyuki Hasegawa

  2. Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan

    Chiharu Tohyama, Chieko Dohmoto & Tohru Kataoka

Authors
  1. Arata Ichiyama
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  2. Hiroyuki Hasegawa
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  3. Chiharu Tohyama
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  4. Chieko Dohmoto
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  5. Tohru Kataoka
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Editor information

Editors and Affiliations

  1. University of Hawaii School of Medicine, Honolulu, Hawaii, USA

    Kerry T. Yasunodu  & Howard F. Mower  & 

  2. Kyoto University Faculty of Medicine, Kyoto, Japan

    Osamu Hayaishi

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© 1976 Plenum Press, New York

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Ichiyama, A., Hasegawa, H., Tohyama, C., Dohmoto, C., Kataoka, T. (1976). Some Properties of Bovine Pineal Tryptophan Hydroxylase. In: Yasunodu, K.T., Mower, H.F., Hayaishi, O. (eds) Iron and Copper Proteins. Advances in Experimental Medicine and Biology, vol 74. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3270-1_9

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  • DOI: https://doi.org/10.1007/978-1-4684-3270-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3272-5

  • Online ISBN: 978-1-4684-3270-1

  • eBook Packages: Springer Book Archive

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