Abstract
A mitochondrial cytochrome P-450 catalyzes the conversion of cholesterol to pregnenolone in the various steroid-forming organs: pregnenolone is converted to the steroid hormones secreted by these organs. The conversion of cholesterol to pregnenolone is commonly called side-chain cleavage (Figure 1). Side-chain cleavage appears to determine the rate of steroid biosynthesis so that the role of P-450 in that reaction is important in considering the regulation steroid production in the whole animal (1–3).
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References
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© 1976 Plenum Press, New York
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Hall, P.F. (1976). The Role of Cytochrome P-450 in the Regulation of Steroid Biosynthesis. In: Yasunodu, K.T., Mower, H.F., Hayaishi, O. (eds) Iron and Copper Proteins. Advances in Experimental Medicine and Biology, vol 74. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3270-1_23
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DOI: https://doi.org/10.1007/978-1-4684-3270-1_23
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