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Generation of Kinin by Plasma Kallikrein and Plasmin and the Effect of α1-Antitrypsin and Antithrombin III on the Kininogenases

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Kinins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 70))

Abstract

The two kininogenases of plasma are kallikrein and plasmin (1). of these proteases kallikrein is more specific, acting almost exclusively on kininogen, whereas plasmin has a much wider spectrum of action, capable of degrading a number of non-specific proteins, e.g. casein. Both enzymes hydrolyse arginine esters, but while kallikrein has little effect on lysine esters, these synthetic substrates are readily hydrolysed by plasmin. Both enzymes are present in plasma as zymogens or proenzymes, kallikrein as prekallikrein (2) and plasmin as plasminogen (3).

Supported by the Atkinson Charitable Foundation, The Ontario Heart Foundation and the Medical Research Council of Canada (MT-1251).

Postdoctoral Fellow supported by the Ontario Heart Foundation.

Holder of an Associateship of the Medical Research Council of Canada.

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Authors and Affiliations

  1. Division of Experimental Pathology, Department of Pathology, and Institute of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ontario, M5S 1A8, Canada

    Flavio M. Habal, Clement E. Burrowes & Henry Z. Movat

Authors
  1. Flavio M. Habal
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  2. Clement E. Burrowes
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  3. Henry Z. Movat
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Editor information

Editors and Affiliations

  1. University of Florence, Florence, Italy

    Federigo Sicuteri

  2. State University of New York, Buffalo, New York, USA

    Nathan Back

  3. Pharmaceutical Research Center, Wuppertal-Elberfeld, West Germany

    Gert L. Haberland

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© 1976 Plenum Press, New York

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Habal, F.M., Burrowes, C.E., Movat, H.Z. (1976). Generation of Kinin by Plasma Kallikrein and Plasmin and the Effect of α1-Antitrypsin and Antithrombin III on the Kininogenases. In: Sicuteri, F., Back, N., Haberland, G.L. (eds) Kinins. Advances in Experimental Medicine and Biology, vol 70. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3267-1_4

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  • DOI: https://doi.org/10.1007/978-1-4684-3267-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3269-5

  • Online ISBN: 978-1-4684-3267-1

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