Abstract
Histamine is a well-known pain producing substance; and its acute administration in essential headache provokes or exacerbates the ache; the chronic administration of histamine can improve headache, probably through a sort of desensitization at the level of the nociceptors. Other pain producing substances, such as kinins, can take part in the mechanism of the histamine desensitization; in fact, histamine and the histamine liberator 48/80, when acutely administered, are able to lower the plasma kininogen level in man (1). Interactions between histamine and the kailikrein-kinin system have been shown by other authors (2,3,4,5,6).
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© 1976 Plenum Press, New York
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Pedata, F., Del Bianco, P.L., Curradi, C., Anselmi, B., Sicuteri, F. (1976). Histamine and Kallikrein System in Man. In: Sicuteri, F., Back, N., Haberland, G.L. (eds) Kinins. Advances in Experimental Medicine and Biology, vol 70. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3267-1_28
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DOI: https://doi.org/10.1007/978-1-4684-3267-1_28
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