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Mechanism of Clostripain-Induced Kinin Release from Human, Rat and Canine Plasma

  • Chapter
Kinins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 70))

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Abstract

Clostripain (clostridiopeptidase B, E.C. 3.4.4.20) is a thiol proteinase found in extracts from cultures of Clostridium histolyticum (Ogle and Tytell, 1953; Labouesse and Gros, 1960), and displays a marked specificity for the carboxyl linkage of arginine (Gros and Labouesse, 1960; Mitchell and Harrington, 1968). Clostripain has been reported to release kinin-like polypeptides directly from bovine or horse kininogen-containing preparations (Prado, et al., 1956; Prado and Prado, 1962). In the course of investigations concerning the haemorrhagic and pro-inflammatory activity of bacterial collagenase (Giroux, Lefort and Vargaftig, 1976) we found that clostripain, a contaminant of one collagenase preparation, displayed indirect kinin-releasing activities which had not been described before. This communication reports our investigation of the mechanism of such release.

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References

  • Back, N. and Steger, R. (1968), Fed. Proc., 27 96–99.

    PubMed  CAS  Google Scholar 

  • Cochrane, C.G., and Wuepper, K.D. (1971), in Immunopathology of Inflammation (B.K. Forscher and J.C. Houck, eds.), Exerpta Medica, Amsterdam, p. 137–145.

    Google Scholar 

  • Eisen, V. (1964), Br. J. Pharmacol., 22. 87–103.

    CAS  Google Scholar 

  • Eisen, V., and Vogt, W. (1970), in Handbook Exp. Pharmacol. 25 (E.G. Erdos, ed.), Springer, Berlin, p. 82–130.

    Google Scholar 

  • Erdos, E.G., McMennamin, M.A., and Wohler, J.R. (1962), Life Sci., 111 765–769.

    Article  Google Scholar 

  • Erdos, E.G., and Sloane, E.M. (1962), Biochem. Pharmacol., 11 585–592.

    Article  PubMed  CAS  Google Scholar 

  • Erspamer, G.F., Negri, L., and Piccinelli, D. (1973), Arch. Pharmacol., 279 61–74.

    Article  CAS  Google Scholar 

  • Ferreira, S.H., and Vane, J.R. (1967), Br. J. Pharmacol., 29 367–377.

    CAS  Google Scholar 

  • Giroux, E.L., Lefort, J., and Vargaftig, B.B. (1976), submitted for publication.

    Google Scholar 

  • Gros, P., and Labouesse, B. (1960), Bull. Soc. Chim. Biol., 42 559–568.

    PubMed  CAS  Google Scholar 

  • Guimaraes, J.A., Lu, R.C., Webster, M.E., and Pierce, J.V. (1974), Fed. Proc, abstract 2431.

    Google Scholar 

  • Habal, F.M., Movat, H.Z., and Burrowes, C.E. (1974), Biochem. Pharmacol., 23 2291–2303.

    Article  PubMed  CAS  Google Scholar 

  • Hamberg, M., (1975), Proc. Nat. Acad. Sci., in press.

    Google Scholar 

  • Hamberg, M., and Samuelsson, B. (1974), Proc. Nat. Acad. Sci., 71 3400–3404.

    Article  PubMed  CAS  Google Scholar 

  • Hamberg, M., Svensson, J., Wakabayashi, T., and Samuelsson, B. (1974), Proc. Nat. Acad. Sci., 71 345–349.

    Article  PubMed  CAS  Google Scholar 

  • Jahrreiss, R., and Habermann, E. (1971), Arch. Pharmacol., 269 85–100.

    CAS  Google Scholar 

  • Kassell, B. (1970), in Methods in Enzymology 19 (G.E. Perlmann and L. Lorand, eds.), Acad. Press, New York, p. 844–852.

    Google Scholar 

  • Labouesse, B., and Gros, P. (1960), Bull. Soc. Chim. Biol., 42 543–558.

    PubMed  CAS  Google Scholar 

  • Lewis, G.P. (1960), Physiol. Rev. 40 647–676.

    PubMed  CAS  Google Scholar 

  • Mitchell, W.M. (1968), Science, 162 374–375.

    Article  PubMed  CAS  Google Scholar 

  • Mitchell, U.M., and Harrington, W.F. (1968), J. Biol. Chem., 243 4683–4692.

    PubMed  CAS  Google Scholar 

  • Nakahara, M. (1974), Biochem. Pharmacol., 23 3009–3015.

    Article  PubMed  CAS  Google Scholar 

  • Ogle, J.D., and Tytell, A.A. (1953), Arch. Biochem. Biophys., 42 327–336.

    Article  CAS  Google Scholar 

  • Piper, P.J., and Vane, J.R. (1969), Nature, 223 20–35.

    Article  Google Scholar 

  • Porter, W.H., Cunningham, L.W., and Mitchell, W.M. (1971), J. Biol. Chem., 246 7675–7682.

    PubMed  CAS  Google Scholar 

  • Prado, J.L. (1970), in Handbook Exp. Pharmacol. 25 (E.G. Erdos, ed.), Springer, Berlin, p. 156–192.

    Google Scholar 

  • Prado, J.L., Monier, R., Prado, E.S., and Fromageot, C. (1956), Biochim. Biophys. Acta, 22 87–95.

    Article  PubMed  CAS  Google Scholar 

  • Prado, J.L., and Prado, E.S. (1962), An. Acad. Bras. Cien., 34 51–55.

    CAS  Google Scholar 

  • Rothschild, A.M. (1967), in Int. Symp. Vaso-Active Polypeptides: Bradykinin and Related Kinins (M. Rocha e Silva and H.A. Rothschild, eds.), Edart, Sao Paulo, p. 197–203.

    Google Scholar 

  • Schoenmakers, J.G.G., Matze, R., Haanen, C., and Zilliken, F. (1965), Biochim. Biophys. Acta, 101 166–176.

    PubMed  CAS  Google Scholar 

  • Trautschold, I. and Werle, E. (1961), Z. Physiol. Chem. 325 48–59.

    Article  CAS  Google Scholar 

  • Vane, J.R. (1964), Br. J. Pharmacol., 23 360–373.

    CAS  Google Scholar 

  • Vane, J.R. (1971), Nature New Biol., 231 232–235.

    PubMed  CAS  Google Scholar 

  • Vargaftig, B.B., Bhargava, N., de Vos, C.J., and Bonta, I.L. (1970), Advan. Exp. Med. Biol., 8 477–485.

    CAS  Google Scholar 

  • Vargaftig, B.B., and Chignard, M. (1975), Agents and Actions, 5 137–144.

    Article  PubMed  CAS  Google Scholar 

  • Vargaftig, B.B., and Dao, N. (1971), Pharmacology, 6 99–108.

    Article  PubMed  CAS  Google Scholar 

  • Vargaftig, B.B., Tranier, Y., and Chignard, M. (1974), Prostaglandins, 8 133–156.

    Article  PubMed  CAS  Google Scholar 

  • Vargaftig, B.B., and Zirinis, P. (1973), Nature New Biol., 244 114–116.

    PubMed  CAS  Google Scholar 

  • Vogt, W. (1966), in Hypotensive Peptides (E.G. Erdos, N. Back and F. Sicuteri, eds.), Springer, Berlin, p. 185–192.

    Chapter  Google Scholar 

  • Willis, A.L. (1974), Prostaglandins, 5 1–25.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre de Recherche Merrell International, 16, rue d’Ankara, 67000, Strasbourg, France

    B. B. Vargaftig & E. L. Giroux

Authors
  1. B. B. Vargaftig
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  2. E. L. Giroux
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Editor information

Editors and Affiliations

  1. University of Florence, Florence, Italy

    Federigo Sicuteri

  2. State University of New York, Buffalo, New York, USA

    Nathan Back

  3. Pharmaceutical Research Center, Wuppertal-Elberfeld, West Germany

    Gert L. Haberland

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© 1976 Plenum Press, New York

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Vargaftig, B.B., Giroux, E.L. (1976). Mechanism of Clostripain-Induced Kinin Release from Human, Rat and Canine Plasma. In: Sicuteri, F., Back, N., Haberland, G.L. (eds) Kinins. Advances in Experimental Medicine and Biology, vol 70. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3267-1_20

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  • DOI: https://doi.org/10.1007/978-1-4684-3267-1_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3269-5

  • Online ISBN: 978-1-4684-3267-1

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