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Transport of Adenine Derivatives in Tissues of the Brain

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Transport Phenomena in the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 69))

Abstract

It will be valuable first to note the ubiquity of adenine derivatives in the brain and some of the effects which can be ascribed to the appearance in extracellular fluids of a small proportion of the tissue’s adenine compounds. Adenine derivatives are prominent components of the small molecular-weight metabolites of the cells of the brain, and also of important categories of their macromolecules, especially of the nucleic acids. Because adenine nucleotides are associated with energy-metabolism, almost all changes in cerebral activities are to some degree associated with changes — of place or of chemical nature or both — in cerebral adenine derivates. The converse is also true; several adenine derivatives when administered to animals alter their behavior in fashions which can be ascribed to changes in cerebral functioning. Examples are quoted in Table 1, which lists also the effects of applying an adenine derivative directly to the mammalian brain and to preparations derived from it.

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Author information

Authors and Affiliations

  1. Institute of Psychiatry, The Maudsley Hospital, Denmark Hill, London, UK

    Henry McIlwain

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  1. Henry McIlwain
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Editors and Affiliations

  1. National Research Council, Rome, Italy

    Giulio Levi

  2. University of Padua Medical School, Padua, Italy

    Leontino Battistin

  3. Research Institute of Neurochemistry, New York, New York, USA

    Abel Lajtha

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© 1976 Plenum Press, New York

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McIlwain, H. (1976). Transport of Adenine Derivatives in Tissues of the Brain. In: Levi, G., Battistin, L., Lajtha, A. (eds) Transport Phenomena in the Nervous System. Advances in Experimental Medicine and Biology, vol 69. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-3264-0_19

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  • DOI: https://doi.org/10.1007/978-1-4684-3264-0_19

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-3266-4

  • Online ISBN: 978-1-4684-3264-0

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