Recognition Factors of the Crayfish and the Generation of Diversity

  • C. R. Jenkin
  • D. Hardy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)


During the last decade there has been a renewed interest in the mechanisms of immunity in the invertebrates. This has been due partly to the desire of immunologists to find a mechanism in these lower forms that may be an evolutionary precursor to the well defined system in the vertebrates. Approaches to this problem have been basically along two lines. It is now well established that invertebrates may have, in their haemolymph, haemagglutinins to erythrocytes from various species of vertebrates. In certain studies it is clear that these haemagglutinins are functionally analogous to the haemagglutinins present in the sera of vertebrates, for example in their presence, the phagocytosis of erythrocytes is enhanced (1–4). A number of investigators have purified haemagglutinins from various species of invertebrates but to date it would appear that there are no structural homologies between these haemagglutinins and the immunoglobulins of the vertebrates (5–12). The second approach and the one that we have chosen has been to concentrate primarily on functional analogies and to concern ourselves with the problem of determining whether the recognition of foreign material by phagocytic cells in the invertebrates depends on the reaction of the foreign material with specific proteins as it does in the vertebrates.


HeLa Cell Phagocytic Cell Sheep Erythrocyte Cytotoxic Reaction Recognition Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Tripp, M.R., J. Invert. Path., 8: 478 (1966).CrossRefGoogle Scholar
  2. 2.
    Stuart, A.E., J. Path. Bact., 96: 401 (1968).PubMedCrossRefGoogle Scholar
  3. 3.
    Prowse, R.H. and Tait, N.T., Immunol., 17: 437 (1969).Google Scholar
  4. 4.
    McKay, D.J. and Jenkin, C.R., Aust.J.exp.Biol. med. Sci., 48:139 (1970).PubMedCrossRefGoogle Scholar
  5. 5.
    Marchalonis, J.J. and Edelman, G.H., J. Mol. Biol., 32: 453 (1968).CrossRefGoogle Scholar
  6. 6.
    Acton, R.T., Bennett, J.C., Evans, E.E. and Schrohenloher, R.E., J. Biol. Chem., 244: 4128 (1969).PubMedGoogle Scholar
  7. 7.
    Hammerstrom, S. and Kabat, E.A., Biochem., 8: 2696 (1969).CrossRefGoogle Scholar
  8. 8.
    Hammerstrom, S., Methods in Enzymology, Vol. XXVIII, Complex Carbohydrates, Part B, p.368 (Academic Press, New York, 1972).Google Scholar
  9. 9.
    Jenkin, C.R. and Rowley, D., Aust. J. exp. Biol. med. Sci., 47: 129 (1970).Google Scholar
  10. 10.
    Finstad, C.L., Litman, G.W., Finstad, J. and Good, R.A., J. Immunol., 108: 1704 (1972).PubMedGoogle Scholar
  11. 11.
    Hall, J.L. and Rowlands, D.T., Biochemistry, 13: 821 (1974).PubMedCrossRefGoogle Scholar
  12. 12.
    Pauley, G.B., Contemporary Topics in Immunobiology, 4: 241 (1974).CrossRefGoogle Scholar
  13. 13.
    Tyson, C.J. and Jenkin, C.R., Aust. J. exp. Biol. med. Sci., 52: 341 (1974).PubMedCrossRefGoogle Scholar
  14. 14.
    Tyson, C.J. and Jenkin, C.R., Aust. J. exp. Biol. med. Sci., 51: 609 (1974).Google Scholar
  15. 15.
    McKay, D.J., Jenkin, C.R. and Rowley, D., Aust. J. exp. Biol. med. Sci., 47: 125 (1969).PubMedCrossRefGoogle Scholar
  16. 16.
    Tyler, A. and Metz, B., J. exp. Zool., 100: 387 (1945).PubMedCrossRefGoogle Scholar
  17. 17.
    Tyson, C.J., Stevens, C. and Jenkin, C.R., Unpublished observations (1975).Google Scholar
  18. 18.
    Cooper, E.L., Transplantation, 3: 332 (1968).Google Scholar
  19. 19.
    Cooper, E.L., J. exp. Zool., 171: 69 (1969).PubMedCrossRefGoogle Scholar
  20. 20.
    Duprat, P.C., Transpl. Proc., 2: 222 (1970).Google Scholar
  21. 21.
    Hildemann, W.H., Dix, T.G., and Collins, J.D., Contemporary Topics in Immunobiology, 4: 141 (1974).CrossRefGoogle Scholar
  22. 22.
    Valembois, P., Contemporary Topics in Immunobiology, 4: 121 (1974).CrossRefGoogle Scholar
  23. 23.
    Tyson, C.J. and Jenkin, C.R., Aust. J. exp. Biol. med. Sci., 52: 915 (1974).CrossRefGoogle Scholar
  24. 24.
    Hellstrom, K.E. and Hellstrom, I., Iso Antigens and Cell Interactions, p.79 (Wister Institute Press, Philadelphia, 1965).Google Scholar
  25. 25.
    Hellstrom, K.E., Hellstrom, I. and Motet, D., Cellular Recognition, p.155 (North Holland Publishing Co., Amsterdam, 1969).Google Scholar
  26. 26.
    Tyson, C.J. and Jenkin, C.R., Unpublished observations (1974).Google Scholar
  27. 27.
    Acton, R.T. and Evans, E.E., In-Vitro, 3: 146 (1968).Google Scholar
  28. 28.
    Cornick, J.W. and Stewart, J.E., J. Invert. Path., 21: 255 (1973).CrossRefGoogle Scholar
  29. 29.
    Fernandez-Moran, H., Marchalonis, J. and Edelman, G.M., J. Mol. Biol., 32: 467 (1968).PubMedCrossRefGoogle Scholar
  30. 30.
    Bhaskaran, S., Unpublished data (1975).Google Scholar
  31. 31.
    Busbridge, W., Unpublished observations (1975).Google Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • C. R. Jenkin
    • 1
  • D. Hardy
    • 1
  1. 1.Department of MicrobiologyThe University of AdelaideAdelaideAustralia

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