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Immunologic Phylogeny pp 383–386Cite as

Demonstration of an Inverse Relationship between Regenerative Capacity and Oncogenesis in the Adult Frog, Rana Pipiens

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 64))

Summary

In a series of 105 adult frogs (Rana pipiens) 19 sarcomas were induced at the implantation site of 3-methylcholanthrene pellets. Two tumors arose first in the control forelimbs, whereas 13 tumors arose first in the denervated forelimb. The remaining tumors occurred in a previously tumor-bearing frog. Ten months was the average latent period required until tumor formation occurred.

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Author information

Authors and Affiliations

  1. The Fox Chase Cancer Center, The Institute for Cancer Research, Phila., Pa., 19111, USA

    H. C. Outzen, R. P. Custer & R. T. Prehn

Authors
  1. H. C. Outzen
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  2. R. P. Custer
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  3. R. T. Prehn
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Editor information

Editors and Affiliations

  1. Hilo College, University of Hawaii, Hilo, Hawaii, USA

    W. H. Hildemann

  2. University of Hawaii at Manoa, Honolulu, Hawaii, USA

    A. A. Benedict

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© 1975 Springer Science+Business Media New York

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Outzen, H.C., Custer, R.P., Prehn, R.T. (1975). Demonstration of an Inverse Relationship between Regenerative Capacity and Oncogenesis in the Adult Frog, Rana Pipiens . In: Hildemann, W.H., Benedict, A.A. (eds) Immunologic Phylogeny. Advances in Experimental Medicine and Biology, vol 64. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3261-9_38

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  • DOI: https://doi.org/10.1007/978-1-4684-3261-9_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3263-3

  • Online ISBN: 978-1-4684-3261-9

  • eBook Packages: Springer Book Archive

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