Mitogens as Probes of Lymphocyte Heterogeneity in Anuran Amphibians
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Based on functional and structural properties, lymphocytes from birds and mammals have been classified into thymus-derived T cell and bursa- or bone marrow-derived B cell populations. Indeed, we now recognize even further heterogeneity of each major population. For several years we have been interested in the phylogeny of such immuno-competent cells. Since ontogenetically all lymphocytes of the anuran amphibian are derived from a single organ source — the thymus (1) — we have focused our research efforts on determining whether comparable heterogeneity exists at this level of vertebrate evolution.
KeywordsPeak Response Stimulation Index Tritiated Thymidine Cell Mitogen Rana Pipiens
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