Abstract
Phytomitogens such as phytohemagglutinin (PHA) and concanavalin A (Con A) bind to cell surface receptors of thymus-derived (T) and bone marrow-derived (B) lymphocytes but stimulate only T-cells to divide and transform into blast cells (1, 2, 3). These mitogens can also stimulate lymphocytes from fish (4, 5, 6, 7) and amphibians (8, 9, 10). In the absence of biological markers at this level of phylogeny, however, evidence is lacking as to whether the responding cells belong to specific lymphocyte subpopulations.
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Reddy, A.L., Wright, R.K. (1975). Synergistic and Antagonistic Effects of Mitogens on Proliferation of Lymphocytes from Spleens of Rana pipiens . In: Hildemann, W.H., Benedict, A.A. (eds) Immunologic Phylogeny. Advances in Experimental Medicine and Biology, vol 64. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3261-9_33
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DOI: https://doi.org/10.1007/978-1-4684-3261-9_33
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