Mitogens as Probes for Studying Temperature Effects on the Development of Immunocompetent Cells in Poikilothermic Vertebrates

  • Richard K. Wright
  • A. Lakshma Reddy
  • Edwin L. Cooper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)


Vertebrate physiological processes take place over a limited temperature range. With the poikilothermic vertebrates (fishes, amphibians and reptiles), their internal body temperature is closely linked to the environmental temperature with little regulation possible. In general, within the thermal tolerance limits of the organism, low temperatures depress, delay or inhibit antibody synthesis and increase allograft survival times whereas high temperatures increase or accelerate antibody synthesis and decrease allograft survival times (1–4).


Spleen Cell Lymphocyte Activation Stimulation Index Immunocompetent Cell Mitogenic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Richard K. Wright
    • 1
  • A. Lakshma Reddy
    • 1
  • Edwin L. Cooper
    • 1
  1. 1.Departments of Anatomy and Microbiology and ImmunologySchool of Medicine and Dental Research Institute, University of CaliforniaLos AngelesUSA

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