Evolution of Conformational Flexibility of Immunoglobulin M

  • Renata E. Cathou
  • David A. Holowka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)


Since the initial observations of Heidelberger and Pederson (1) of a macroglobulin antibody against pneumococcus in the horse, IgM has been recognized as a major class of immunoglobulins in mammals as well as in vertebrates as phylogenetically distant as the elasmobranchii (2). In fact, IgM appears to be the first recognizable class to have evolved. It still is the first immunoglobulin to be synthesized in a mammalian immune response.


Conformational Flexibility Rigid Sphere Rotational Correlation Time Nurse Shark Segmental Flexibility 
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  1. 1.
    Heidelberger, M. and Pederson, K.O. (1937). J. Exp. Med. 65, 393.PubMedCrossRefGoogle Scholar
  2. 2.
    Marchalonis, J. and Edelman, G.M. (1965). J. Exp. Med. 122, 601.PubMedCrossRefGoogle Scholar
  3. 3.
    Metzger, H. (1970). Adv. in Immunol. 12, 57.CrossRefGoogle Scholar
  4. 4.
    Koshland, M.E. (1975). Adv. in Immunol. 20, 41.CrossRefGoogle Scholar
  5. 5.
    Kim, Y.D. and Karush, F. (1973). Immunochemistry, 10, 365.PubMedCrossRefGoogle Scholar
  6. 6.
    Plaut, A.G., Cohen, S. and Tomasi, T.B., Jr. (1972). Science 176, 55.PubMedCrossRefGoogle Scholar
  7. 7.
    Pierce, C.W., Asofsky, R. and Solliday, S.M. (1973). Federation Proceedings, 32, 41.PubMedGoogle Scholar
  8. 8.
    Putnam, F.W., Florent, G., Paul, C., Shinoda, T., Shimizu, A. (1973). Science 182, 287.PubMedCrossRefGoogle Scholar
  9. 9.
    Watanabe, S., Barnikol, H.V., Horn, J. and Hilschmann, N. (1973). Hoppe-Seyler’s Z. Physiol. Chem. 354, 1505.PubMedGoogle Scholar
  10. 10.
    Dorrington, K.J. and Mihaesco, C. (1970). Immunochemistry 7, 651.PubMedCrossRefGoogle Scholar
  11. 11.
    Yguerabide, J., Epstein, H.F. and Stryer, L. (1970). J. Mol. Biol. 51, 573.PubMedCrossRefGoogle Scholar
  12. 12.
    Putnam, F.W. (1974), in Prog. in Immunol. II, ed. L. Brent and J. Holborow, volume 1, 25.Google Scholar
  13. 13.
    Weber, G. (1953). Adv. in Portein Chem. 8, 415.CrossRefGoogle Scholar
  14. 14.
    Stryer, L. (1968). Science 162, 526.PubMedCrossRefGoogle Scholar
  15. 15.
    Yguerabide, J. (1972), in Methods in Enzymology, Volume 26, Part C, ed. C. H. W. Hirs and S. N. Timasheff, Academic Press, N. Y. p. 498.Google Scholar
  16. 16.
    Holowka, D.A. and Cathou, R.E. Manuscript in preparation.Google Scholar
  17. 17.
    Holowka, D.A. and Cathou, R.E. (1974). Federation Proceedings 33, 1320.Google Scholar
  18. 18.
    Parker, C.W., Yoo, J.J., Johnson, M.C. and Godt, S.M. (1967). Biochemistry 6, 3408.PubMedCrossRefGoogle Scholar
  19. 19.
    Kim, Y.D. and Karush, F. (1974). Immunochemistry 11, 147.PubMedCrossRefGoogle Scholar
  20. 20.
    Beale, D. (1974). FEBS Letters. 44, 236.PubMedCrossRefGoogle Scholar
  21. 21.
    Lovejoy, C., Holowka, D.A. and Cathou, R.E. (1975). Manuscript in preparation.Google Scholar
  22. 22.
    Feinstein, A. and Munn, E.A. (1969). Nature 224, 1307.PubMedCrossRefGoogle Scholar
  23. 23.
    Klapper, D.G., Clem, L.W., and Small, P.A., Jr. (1971). Biochemistry 10, 645.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Renata E. Cathou
    • 1
  • David A. Holowka
    • 1
  1. 1.Department of Biochemistry and PharmacologyTufts University School of MedicineBostonUSA

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