Immunoglobulins in Ranid Frogs and Tadpoles

  • L. A. Steiner
  • C. A. Mikoryak
  • A. D. Lopes
  • C. Green
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)


One approach to gain insight into the evolution of the immune system is to investigate the structure of the immunoglobulins (Igs) in a variety of species. The results of such studies (reviewed in reference 1) have usually been interpreted to indicate that the diversity of the Ig classes increases in the course of evolution. Thus, most primitive vertebrates (e.g., cartilaginous and bony fish) have Igs that apparently correspond to mammalian IgM, whereas most higher vertebrates have 2 or more Ig classes. To understand how the Igs in these various groups of animals are related to one another, it is necessary to obtain detailed information regarding their structure.


Sodium Dodecyl Sulfate High Molecular Weight Light Chain Heavy Chain Free Light Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Kubo, R.T., Zimmerman, B. and Grey, H.M., in The Antigens, M. Sela, ed., Vol. I, p. 417 (Academic Press, New York, 1973).Google Scholar
  2. 2.
    Geczy, C.L., Green, P.C. and Steiner, L.A., J. Immunol., 111: 1261 (1973).PubMedGoogle Scholar
  3. 3.
    Green, C. and Steiner, L.A., to be published.Google Scholar
  4. 4.
    Marchalonis, J. and Edelman, G.M., J. Exp. Med., 124: 901 (1966).PubMedCrossRefGoogle Scholar
  5. 5.
    Frieden, E., in Metamorphosis: A Problem in Developmental Biology, W. Etkin and L.I. Gilbert, eds., p. 349 (Appleton-Century-Crofts, New York, 1968).Google Scholar
  6. 6.
    Witschi, E., Development of Vertebrates, p. 78 (Saunders, Philadelphia, 1956).Google Scholar
  7. 7.
    Shore, S.L., Phillips, D.J. and Reimer, C.B., Immunochemistry, 8: 562 (1971).PubMedCrossRefGoogle Scholar
  8. 8.
    Geczy, C.L., Green, P.C., Gaydos, K.C. and Steiner, L.A., Fed. Proc, 31: 750 (1972).Google Scholar
  9. 9.
    Ambrosius, H., Hemmerling, J., Richter, R. and Schimke, R., in Developmental Aspects of Antibody Formation and Structure, J. Šterzl and I. Říha, eds., Vol. II, p. 727 (Academic Press, New York, 1970).Google Scholar
  10. 10.
    Gitlin, D., Perricelli, A. and Gitlin, J.D., Comp. Biochem. Physiol., 44B: 225 (1973).Google Scholar
  11. 11.
    Romano, E.L., Geczy, C.L. and Steiner, L.A., Immunochemistry, 10: 655 (1973).PubMedCrossRefGoogle Scholar
  12. 12.
    Grey, H.M., Abel, C.A., Yount, W.J. and Kunkel, H.G., J. Exp. Med., 128: 1223 (1968).PubMedCrossRefGoogle Scholar
  13. 13.
    Abel, C.A. and Grey, H.M., Biochemistry, 7: 2682 (1968).PubMedCrossRefGoogle Scholar
  14. 14.
    Vaerman, J.P., Lebacq-Verheyden, A.M. and Heremans, J.F., Immunol. Comm., 3: 239 (1974).Google Scholar
  15. 15.
    Hadji-Azimi, I., Immunology, 21: 463 (1971).PubMedGoogle Scholar
  16. 16.
    Tung, J-S. and Knight, C.A., Biochem. Biophys. Res. Commun., 42: 1117 (1971).PubMedCrossRefGoogle Scholar
  17. 17.
    Segrest, J.P., Jackson, R.L., Andrews, E.P. and Marchesi, V.T., Biochem. Biophys. Res. Commun., 44: 390 (1971).PubMedCrossRefGoogle Scholar
  18. 18.
    Leslie, G.A. and Clem, L.W., J. Exp. Med., 130: 1337 (1969).PubMedCrossRefGoogle Scholar
  19. 19.
    Zimmerman, B., Shalatin, N. and Grey, H.M., Biochemistry, 10: 482 (1971).PubMedCrossRefGoogle Scholar
  20. 20.
    Leslie, G.A. and Clem, L.W., J. Immunol., 108: 1656 (1972).PubMedGoogle Scholar
  21. 21.
    Du Pasquier, L., Current Topics in Microbiology and Immunology, 61: 37 (1973).PubMedGoogle Scholar
  22. 22.
    Marchalonis, J.J., Develop. Biol., 25: 479 (1971).PubMedCrossRefGoogle Scholar
  23. 23.
    Moticka, E.J., Brown, B.A. and Cooper, E.L., J. Immunol., 110: 855 (1973).PubMedGoogle Scholar
  24. 24.
    Aggarwal, S.J. and Riggs, A., J. Biol. Chem., 244: 2372 (1969).PubMedGoogle Scholar
  25. 25.
    Maniatis, G.M. and Ingram, V.M., J. Cell Biol., 49: 380 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • L. A. Steiner
    • 1
  • C. A. Mikoryak
    • 1
  • A. D. Lopes
    • 1
  • C. Green
    • 1
  1. 1.Dept. of BiologyMassachusetts Institute of TechnologyCambridgeUSA

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