Preliminary Structural Characterization of Pacific Hagfish Immunoglobulin

  • A. E. De Ioannes
  • W. H. Hildemann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 64)


The immune capacities of primitive fishes of the class Agnatha, the lamprey and the hagfish, have been under study for nearly a decade. Early results from Good and his collaborators suggested that lampreys, but not hagfish, possessed an adaptive immune response (1, 2). However, subsequent work of Linthicum and Hildemann (3) and Hildemann and Thoenes (4, 5) showed that hagfish (Eptatretus stoutii) could also respond specifically to certain immunogens and could reject allografts under appropriate conditions.


Sodium Dodecyl Sulfate Light Chain Heavy Chain Sucrose Gradient Light Chain Region 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • A. E. De Ioannes
    • 1
  • W. H. Hildemann
    • 1
  1. 1.Department of Microbiology and Immunology and Dental Research InstituteUniversity of CaliforniaLos AngelesUSA

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