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Lipoproteins and Lipid Transport

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Lipids, Lipoproteins, and Drugs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 63))

Abstract

Lipids are transported in blood plasma in association with proteins. Some polar lipids are transported by albumin (free fatty acids, bile acids) or by specific binding proteins (retinol-binding protein). Nonpolar lipids are transported in large complexes containing polar lipids and specific apoproteins (which serve functions beyond that of “packaged”). These complexes comprise the macromolecular particles that we generally think of when we apply the term “lipoproteins” to blood plasma and other extracellular fluids. These lipoproteins and their role in transport of nonpolar lipids are the subject of this short and eclectic review.

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Abbreviations

VLDL:

LDL and HDL are very low density, low density and high density lipoproteins

LCAT:

lecithin-cholesterol acyl transferase

A:

apoproteins refer to the two major apoproteins of HDL, B-apoprotein to the major apoprotein of LDL and C-apoproteins to the three proteins of low molecular weight that are shared between VLDL and HDL in humans and rats.

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Author information

Authors and Affiliations

  1. Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California, USA

    Richard J. Havel

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  1. Richard J. Havel
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Editor information

Editors and Affiliations

  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    Rodolfo Paoletti

  3. Division of Research, The Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes

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© 1975 Plenum Press, New York

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Havel, R.J. (1975). Lipoproteins and Lipid Transport. In: Kritchevsky, D., Paoletti, R., Holmes, W.L. (eds) Lipids, Lipoproteins, and Drugs. Advances in Experimental Medicine and Biology, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3258-9_3

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  • DOI: https://doi.org/10.1007/978-1-4684-3258-9_3

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