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Mucopolysaccharide-Lipoprotein Complexes in Atherosclerotic Aorta

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Arterial Mesenchyme and Arteriosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 43))

Abstract

The carbohydrate macromolecules present in the arterial wall represent families of complex compounds (Berenson et al., 1971). Although widely distributed throughout the body in all mesenchymal structures, the macromolecules are particularly important to the cardiovascular system. Most studies, including our own, over the past two decades have served largely to describe connective tissue compounds taxonomically, and have not been able to clearly define their function. That connective tissue elements form an integral part of the cardiovascular system is fundamental; still, the task remains to bridge the gap between morphological, biochemical changes of connective tissues, and the functional nature of these changes.

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References

  • Amenta, J.S., and Waters, L.L. (1960–1961). The precipitation of serum lipoproteins by mucopolysaccharides extracted from aortic tissue. Yale J. Biol. Med. 33, 112.

    Google Scholar 

  • Berenson, G.S. (1959). Distribution of acid mucopolysaccharides in inner and outer layers of bovine aorta. Circ. Res. 7, 889.

    Google Scholar 

  • Berenson, G.S., Radhakrishnamurthy, B., Dalferes, E.R., Jr., and Srinivasan, S.R. (1971). Carbohydrate macromolecules and atherosclerosis. Hum. Pathol. 2, 57.

    Google Scholar 

  • Berenson, G.S., Srinivasan, S.R., Lopez-S., A., Radhakrishnamurthy, B., Pargaonkar, P.S., and Deupree, R.H. (1972a). Clinical application of an indirect method for quantitating serum lipoproteins. Clin. Chim. Acta 36, 175.

    Google Scholar 

  • Berenson, G.S., Srinivasan, S.R., Pargaonkar, P.S., Radhakrishnamurthy, B., and Dalferes, E.R., Jr. (1972b). A simplified primary screening procedure for the detection of hyperlipidemias in “normal” individuals. Clin. Chem. 18, 1463.

    Google Scholar 

  • Bernfeld, P., Nisselbaum, J.S., Berkeley, B.J., and Hanson, R.W. (1960). The influence of chemical and physiochemical nature of macromolecular polyanions on their interaction with human serum ß-lipoproteins. J. Biol. Chem. 235, 2852.

    Google Scholar 

  • Bihari-Varga, M., and Vegh, M. (1967). Quantitative studies on the complexes formed between aortic mucopolysaccharides and serum lipoproteins. Biochim. Biophys. Acta 144, 202.

    Google Scholar 

  • Bunting, C.H., and Bunting, H. (1953). Acid mucopolysaccharides of the aorta. Arch. Pathol. 55, 257.

    Google Scholar 

  • Burstein, M., and Samaille, J. (1955). Sur la clarification du serum lipemique par l’heparin in vitro. C.R. Acad. Sci. ( Paris ), 241, 664.

    Google Scholar 

  • Cornwell, D.G., and Kruger, F.A. (1961). Molecular complexes in the isolation and characterization of plasma lipoproteins. J. Lipid Res. 2, 110.

    PubMed  CAS  Google Scholar 

  • Dalferes, E.R., Jr., Ruiz, H., Kumar, V., Radhakrishnamurthy, B., and Berenson, G.S. (1971). Mucopolysaccharides of fatty streaks in young human male aortas. Atherosclerosis 13, 121.

    Article  PubMed  CAS  Google Scholar 

  • Gresham, G.A., and Howard, A.N. (1961). The histogenesis of the atherosclerotic “fatty streak.” J. Atheroscler. Res. 1, 413.

    Google Scholar 

  • Hauss, W.H., Gerlach, G., Junge-Hülsing, H., Themann, H., and Wirth, W. (1969). Studies on the “nonspecific mesenchymal reaction” and the “transit zone” in myocardial lesions and atherosclerosis. Ann. N.Y. Acad. Sci. 156, 207.

    Google Scholar 

  • Iverius, P.H. (1972). The interaction between human plasma lipoproteins and connective tissue glycosaminoglycans. J. Biol. Chem. 247, 2607.

    Google Scholar 

  • Kramsch, D.M., and Hollander, W. (1973). The interaction of serum and arterial intima and its role in the lipid accumulation in atherosclerotic plaques. J. Clin. Invest. 52, 236.

    Google Scholar 

  • Kumar, V., Berenson, G.S., Ruiz, H., Dalferes, E.R., Jr., Strong, J.P. (1967a). Acid mucopolysaccharides of human aorta: II. Variations with atherosclerotic involvement. J. Atheroscler. Res. 7, 573.

    Google Scholar 

  • Kumar, V., Berenson, G.S., Ruiz, H., Dalferes, E.R., Jr., Strong, J.P. (1967b). Acid mucopolysaccharides of human aorta: I. Variations with maturation. J. Atheroscler. Res. 7, 573.

    Google Scholar 

  • Meyer, K., Davidson, E., Linker, A., and Hoffman, P. (1956). Acid mucopolysaccharides of connective tissue. Biochem. Biophys. Acta 21, 506.

    Google Scholar 

  • Mórner, K.T. (1895). Einige Beobachtungen über die Verbreitung der Chondroitin-Schwefelsäure. Z. Physiol. Chem. 20, 357.

    Google Scholar 

  • Rinehart, J.F. (1954). Observations on the histogenesis and pathogenesis of arteriosclerosis. In “Connective Tissue in Health and Disease.” (G. Asboe-Hansen, ed.), pp. 239–250. Ejnar Munksgaard, Copenhagen.

    Google Scholar 

  • Ross, R., and Glomset, J.A. (1973). Atherosclerosis and the arterial smooth muscle cell. Science 180, 1332.

    Article  PubMed  CAS  Google Scholar 

  • Smith, E.B., Evans, P.H., and Downham, M.D. (1967). Lipids in the aortic intima: The correlation of morphological and chemical characteristics. J. Atheroscler. Res. 7, 171.

    Google Scholar 

  • Smith, E.B., Slater, R.S., and Chu, P.K. (1968). The lipids in raised fatty and fibrous lesions in human aorta: A comparison of the changes at different stages. J. Atheroscler. Res. 8, 399.

    Google Scholar 

  • Srinivasan, S.R., Dolan, P., Radhakrishnamurthy, B., and Berenson, G.S. (1972). Isolation of lipoprotein acid mucopolysaccharide complexes from fatty streaks of human aortas. Atherosclerosis 16, 95.

    Article  PubMed  CAS  Google Scholar 

  • Srinivasan, S.R., Lopez-S., A., Radhakrishnamurthy, B., Berenson, G.S. (1970). Complexing of serum -lipoproteins and acid mucopolysaccharides. Atherosclerosis 12, 321.

    CAS  Google Scholar 

  • Taylor, H.E. (1953). The role of mucopolysaccharides in the pathogenesis of intimal fibrosis and atherosclerosis of the human aorta. Amer. J. Pathol. 29, 871.

    Google Scholar 

  • Tracy, R.E., Merchant, E.B., and Kao, V.C. (1961). On the antigenic identity of human serum beta and alpha-2 lipoproteins, and their identification in aortic intima. Circ. Res. 9, 472.

    Google Scholar 

  • Virchow, R. (1856). Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Meidinger Sohn u. Comp., Frankfurt a.M.

    Google Scholar 

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© 1974 Plenum Press, New York

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Berenson, G.S., Srinivasan, S.R., Radhakrishnamurthy, B., Dalferes, E.R. (1974). Mucopolysaccharide-Lipoprotein Complexes in Atherosclerotic Aorta. In: Wagner, W.D., Clarkson, T.B. (eds) Arterial Mesenchyme and Arteriosclerosis. Advances in Experimental Medicine and Biology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3243-5_7

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  • DOI: https://doi.org/10.1007/978-1-4684-3243-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3245-9

  • Online ISBN: 978-1-4684-3243-5

  • eBook Packages: Springer Book Archive

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