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Proliferation of Arterial Cells in Atherosclerosis

  • Chapter
Arterial Mesenchyme and Arteriosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 43))

Abstract

The role of cell proliferation in atherosclerosis has received much attention. It has been suggested for many years that the increase in cells during the formation of intimal lesions may be due to intrinsic proliferation. This hypothesis was based mainly on the observation of mitotic figures in the smooth muscle and foam cells of atherosclerotic plaques, even though mitoses were seen only rarely. On the other hand, it was proposed but never definitely established that migration of cells from the circulation, endothelium or media accounts for the cellular growth of the lesions. Monocytes, endothelial cells, and medial smooth muscle cells thus have been implicated.

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Authors and Affiliations

  1. Department of Pathology, Louisiana State University School of Medicine, New Orleans, Louisiana, USA

    H. C. Stary

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  1. H. C. Stary
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Editors and Affiliations

  1. Department of Comparative Medicine, Arteriosclerosis Research Center, The Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA

    William D. Wagner  & Thomas B. Clarkson  & 

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© 1974 Plenum Press, New York

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Stary, H.C. (1974). Proliferation of Arterial Cells in Atherosclerosis. In: Wagner, W.D., Clarkson, T.B. (eds) Arterial Mesenchyme and Arteriosclerosis. Advances in Experimental Medicine and Biology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3243-5_4

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  • DOI: https://doi.org/10.1007/978-1-4684-3243-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3245-9

  • Online ISBN: 978-1-4684-3243-5

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