Morphology of Mesenchymal Elements of Normal Artery, Fatty Streaks, and Plaques

Geer, Jack C.; Webster, William S.

doi:10.1007/978-1-4684-3243-5_2

Jack C. Geer² &
William S. Webster²

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 43))

61 Accesses
7 Citations

Abstract

The objective of this paper is to review briefly normal arterial structure and the cells found in the various types of human atherosclerotic lesions, and to contrast the cellular reaction of human lesions with that in certain experimental models. There is a striking similarity between the mesenchymal cell reaction in human lesions and that in the experimental models, indicating that the models are valid for studying certain aspects of the pathogenesis of atherosclerosis. Our studies support the conclusion of many other investigators (Altschul, 1950; Björkerud, 1969; Hassler, 1970; Jores, 1924; Lee et al., 1970; McMillan and Stary, 1968; Poole et al., 1971) that the source of the mesenchymal or smooth muscle cells in the intima is medial cells that have proliferated and migrated into the intima.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 39.99; Price excludes VAT (USA)

Softcover Book: USD 54.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

References

Abdulla, Y.H., Adams, C.W.M., and Morgan, R.S. (1967). J. Pathol. Bacteriol. 94, 63.
Article PubMed CAS Google Scholar
Altschul, R. (1944). Arch. Pathol. 38, 305.
Google Scholar
Altschul, R. (1950). “Selected Studies on Arteriosclerosis,” Charles C Thomas, Springfield, Illinois.
Google Scholar
Altschul, R. (1954). “Endothelium,” Macmillan, New York.
Google Scholar
Anitschkow, N. (1933). In “Arteriosclerosis, A Survey of the Problem” (E.V. Cowdry, ed.), pp. 271–322. Macmillan, New York.
Google Scholar
Aschoff, L. (1924). In “Lectures on Pathology,” pp. 131–153. Paul B. Hoeber, New York.
Google Scholar
Balis, J.U., Haust, M.D., and More, R.H. (1964). Exp. Mol. Pathol. 3, 511.
Article Google Scholar
Balis, J.U., Chan, A.S., and Conen, P.E. (1968). Exp. Mol. Pathol. 8, 90.
Article PubMed CAS Google Scholar
Becker, C.G., and Murphy, G.E. (1969). Amer. J. Pathol. 55, 1.
CAS Google Scholar
Björkerud, S. (1969). Virchows Arch. Abt. A. Pathol. Anat. 347, 197.
Google Scholar
Buck, R.C. (1963). In “Atherosclerosis and Its Origin” (M. Sandler and G.H. Bourne, eds.), pp. 1–38. Academic Press, New York.
Google Scholar
Cliff, W.J. (1967). Lab. Invest. 17, 599.
PubMed CAS Google Scholar
Cliff, W.J. (1970). Exp. Mol. Pathol. 13, 1972.
Google Scholar
Cooke, P.H., and Smith, S.C. (1968). Exp. Mol. Pathol. 8, 171.
Article PubMed CAS Google Scholar
Daoud, A.S., Jones, R., and Scott, R.F. (1968). Exp. Mol. Pathol. 8, 263.
Article PubMed Google Scholar
Dewey, M.M., and Barr, L. (1962). Science 137, 670.
Article PubMed CAS Google Scholar
Dock, W. (1931). J. Amer. Med. Ass. 131, 875.
Article Google Scholar
Duff, G.L. (1935a). Arch. Pathol. 20, 81.
CAS Google Scholar
Duff, G.L. (1935b). Arch. Pathol. 20, 259.
Google Scholar
Duff, G.L., and McMillan, G.C. (1951). Amer. J. Med. 11, 92.
Article PubMed CAS Google Scholar
Fangman, R.J., and Hellwig, C.A. (1947). Amer. J. Pathol. 23, 901.
CAS Google Scholar
Florey, H.W., Greer, S.J., Poole, J.C.F., and Werthessen, N.T. (1961). Brit. J. Exp. Pathol. 42, 236.
CAS Google Scholar
Geer, J.C., McGill, H.C., Jr., Strong, J.P., and Holman, R.L. (1960). Proc. Soc. Exp. Biol. Med. 19, 15.
Google Scholar
Geer, J.C., McGill, H.C., and Strong, J.P. (1961). Amer. J. Pathol. 38, 263.
Google Scholar
Geer, J.C. (1965a). Amer. J. Pathol. 47, 241.
CAS Google Scholar
Geer, J.C. (1965b). Lab. Invest. 14, 1764.
CAS Google Scholar
Geer, J.C. (1966). In “Cerebral Vascular Diseases” (C.H. Millikan, R.G. Siekert and J.P. Whisnant, eds.), Vol. 5, pp. 37–52. Grune and Stratton, New York.
Google Scholar
Geer, J.C., and McGill, H.C., Jr. (1967). In “Atherosclerotic Vascular Disease” (A.N. Brest and J.H. Moyer, eds.), pp. 8–22. Appleton-Century-Crofts, New York.
Google Scholar
Geer, J.C., Catsulis, C., McGill, H.C., Jr., and Strong, J.P. (1968a). Amer. J. Pathol. 52, 265.
CAS Google Scholar
Geer, J.C., McGill, H.C., Jr., Robertson, W.B., and Strong, J.P. (1968b). Lab. Invest. 18, 565.
CAS Google Scholar
Geer, J.C., and Haust, M.D. (1972). “Smooth Muscle Cells in Atherosclerosis”. Monographs on Atherosclerosis (O.J. Pollak, H.S. Simms and J.E. Kirk, eds.), Vol. II, Phiebig - S. Karger, Basel.
Google Scholar
Ghani, A.R., and Tibbs, D.J. (1962). Brit. Med. J. 1, 1244.
Article PubMed CAS Google Scholar
Ghidoni, J.J., and O’Neal, R.M. (1967). Exp. Mol. Pathol. 7, 378.
Google Scholar
Gross, L., Epstein, E.Z., and Kugel, M.A. (1934). Amer. J. Pathol. 10, 253.
CAS Google Scholar
Hassler, O. (1970). Lab. Invest. 22, 286.
PubMed CAS Google Scholar
Haust, M.D., Balis, J.U., and More, R.H. (1962). Circulation 26, 656.
Google Scholar
Haust, M.D., and More, R.H. (1966). Circulation 34, 14.
Google Scholar
Haust, M.D. (1970). In “Atherosclerosis: Proceedings of the Second International Symposium, 1969” (R.J. Jones, ed.), pp. 12–20. Springer-Verlag, New York.
Google Scholar
Haust, M.D. (1971a). Hum. Pathol. 2, 1.
Article CAS Google Scholar
Haust, M.D. (1971b). In “Concepts of Disease” (J.G. Brunson and E.A. Gall, eds.), pp. 451–487. Macmillan, New York.
Google Scholar
Hoff, H.F., and Gottlob, R. (1968). Virchows Arch. Pathol. Anat. Physiol. 345, 93.
CAS Google Scholar
Jores, L. (1922). Deut. Med. Wochenschr. 48, 649.
Google Scholar
Jores, L. (1924). In “Handbuch der Speziellen Pathologischen Anatomie und Histologie”. Band II, Herz und Gefässe (F. Henke and O. Lubarsch, eds.), pp. 608–786. Julius Springer, Berlin.
Google Scholar
Jorgensen, L., Rowsell, H.C., Hovig, T., and Mustard, J.F. (1967). Amer. J. Pathol. 51, 681.
CAS Google Scholar
Kadar, A., Veress, B., and Jellinek, H. (1969). Exp. Mol. Pathol. 11, 212.
Article PubMed CAS Google Scholar
Karrer, H.E. (1961). J. Ultrastruct. Res. 5,1.
Article PubMed CAS Google Scholar
Keech, M.K. (1960). J. Biophys. Biochem. Cytol. 7, 533.
Article PubMed CAS Google Scholar
Kuntz, A., and Sulkin, N.M. (1949). Arch. Pathol. 47, 248.
CAS Google Scholar
Langhans, T. (1866). Virchows Arch., Pathol. Anat. Physiol. 36, 187.
Article Google Scholar
Lee, K.T., Lee, K.J., Lee, S.K., Imai, H., and O’Neal, R.M. (1970). Exp. Mol. Pathol. 13, 118.
Article PubMed CAS Google Scholar
Marshall, J.R., Adams, J.G., O’Neal, R.M., and DeBakey, M.E. (1966). J. Atheroscler. Res. 6, 120.
Article PubMed CAS Google Scholar
Marshall, J.R., and O’Neal, R.M. (1966). Exp. Mol. Pathol. 5,1.
Article PubMed CAS Google Scholar
McMillan, G.C., and Stary, H.C. (1968). Ann. N.Y. Acad. Sci. 149, 699.
Article PubMed CAS Google Scholar
Moss, N.S., and Benditt, E.P. (1970a). Lab. Invest. 22, 166.
CAS Google Scholar
Moss, N.S., and Benditt, E.P. (1970b). Lab. Invest. 23, 521.
CAS Google Scholar
Moss, N.S., and Benditt, E.P. (1970c). Lab. Invest. 23, 231.
CAS Google Scholar
Murray, M., Schrodt, G.R., and Berg, H.F. (1966). Arch. Pathol. 82, 138.
PubMed CAS Google Scholar
O’Neal, R.M., Still, W.J.S., and Hartroft, W.S. (1961). J. Pathol. Bacteriol. 82, 183.
Article PubMed Google Scholar
O’Neal, R.M., Jordan, G.L., Jr., Rabin, E.R., DeBakey, M.E., and Halpert, B. (1964). Exp. Mol. Pathol. 3, 403.
Article Google Scholar
Pallaske, G. (1930). Frankfurt. Z. Pathol. 40, 64.
Google Scholar
Parker, F. (1958). Amer. J. Anat. 103, 247.
Article PubMed CAS Google Scholar
Parker, F. (1960). Amer. J. Pathol. 36, 19.
CAS Google Scholar
Parker, F., and Odland, G.F. (1966). Amer. J. Pathol. 48, 197.
CAS Google Scholar
Paule, W.J. (1963). J. Ultrastruct. Res. 8, 219.
Article PubMed CAS Google Scholar
Pease, D.C., and Molinari, S. (1960). J. Ultrastruct. Res. 3, 447.
Article PubMed CAS Google Scholar
Pease, D.C., and Paule, W.J. (1960). J. Ultrastruct. Res. 3, 469.
Article PubMed CAS Google Scholar
Poole, J.C.F., Cromwell, S.B., and Benditt, E.P. (1971). Amer. J. Pathol. 62, 391.
CAS Google Scholar
Prior, J.T., and Jones, D.B. (1952). Amer. J. Pathol. 28, 937.
CAS Google Scholar
Puchtler, H., Sweat, F., Terry, M.S., and Conner, H.M. (1968). J. Microsc. 89, 95.
Article Google Scholar
Rhodin, J.A.G. (1962). Physiol. Rev. 42, Suppl. 5, 48.
CAS Google Scholar
Ross, R., Everett, N.B., and Tyler, R. (1970). J. Cell Biol. 44, 645.
Article PubMed CAS Google Scholar
Ross, R. (1972). In “The Pathogenesis of Atherosclerosis” (R.W. Wissler and J.C. Geer, eds.), pp. 147–163. Williams and Wilkins, Baltimore.
Google Scholar
Sappington, S.W., and Horneff, J.A. (1941). Amer. J. Med. Sci. 201, 862.
Article Google Scholar
Schlicter, J.G. (1946). Arch. Pathol. 42, 182.
Google Scholar
Schönheimer, R. (1924). Virchows Arch., Pathol. Anat. Physiol. 251, 732.
Article Google Scholar
Simpson, C.F., and Harms, R.H. (1969). J. Atheroscler. Res. 10, 63.
Article PubMed CAS Google Scholar
Spaet, T.H., and Lenjnieks, I. (1967). Proc. Soc. Exp. Biol. Med. 125, 1197.
PubMed CAS Google Scholar
Sparagen, S.C., Bond, V.P., and Dahl, L.K. (1962). Circ. Res. 11, 329.
Google Scholar
Ssolowjew, A. (1929). Z. Gesamte Exp. Med. 69, 94.
Article Google Scholar
Still, W.J.S., and O’Neal, R.M. (1962). Amer. J. Pathol. 40, 21.
CAS Google Scholar
Still, W.J.S., and Marriott, P.R. (1964). J. Atheroscler. Res. 4, 373.
Article PubMed CAS Google Scholar
Still, W.J.S. (1966). Lab. Invest. 15, 1492.
PubMed CAS Google Scholar
Still, W.J.S., Ghani, A.R., and Dennison, S.M. (1967). Amer. J. Pathol. 51, 1013.
CAS Google Scholar
Taylor, C.B., Baldwin, D.R., and Hass, G.M. (1950. Arch. Pathol. 49, 623.
Google Scholar
Ts’ao, C., and Glagov, S. (1970). Lab. Invest. 23, 510.
PubMed Google Scholar
Vlodaver, Z., Kahn, H.A., and Neufeld, H.N. (1969). Circulation 39, 541.
PubMed CAS Google Scholar
Wacker, L., and Hueck, W. (1913). Muenchen. Med. Wochenschr. 60, 2097.
Google Scholar
Webster, W.S., Bishop, S.P., and Geer, J.C. (1973). (In Preparation).
Google Scholar
Wilens, S.L. (1951). Amer. J. Pathol. 27, 825.
CAS Google Scholar

Download references

Author information

Authors and Affiliations

Departments of Pathology and Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA
Jack C. Geer & William S. Webster

Authors

Jack C. Geer
View author publications
You can also search for this author in PubMed Google Scholar
William S. Webster
View author publications
You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

Department of Comparative Medicine, Arteriosclerosis Research Center, The Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA
William D. Wagner & Thomas B. Clarkson &

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Geer, J.C., Webster, W.S. (1974). Morphology of Mesenchymal Elements of Normal Artery, Fatty Streaks, and Plaques. In: Wagner, W.D., Clarkson, T.B. (eds) Arterial Mesenchyme and Arteriosclerosis. Advances in Experimental Medicine and Biology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3243-5_2

Download citation

DOI: https://doi.org/10.1007/978-1-4684-3243-5_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3245-9
Online ISBN: 978-1-4684-3243-5
eBook Packages: Springer Book Archive

Publish with us

Policies and ethics