Hormone-Receptor Interactions with the Genome of Eucaryotic Target Cells

  • Bert W. O’Malley
  • William T. Schrader
  • Thomas C. Spelsberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 36)


Progesterone induces de novo synthesis of the specific protein avidin in estrogen-primed chick oviducts. The specificity and kinetics of induction of this protein has been the subject of a series of past publications from our laboratory (1–6). We have previously shown that progesterone causes major quantitative and qualitative alterations in oviduct gene transcription. Induction of avidin was blocked by actinomycin D. Changes in rapidly-labeled nuclear RNA and nuclear RNA polymerase activities supported a transcriptional effect of the hormone (4–7).


Scatchard Plot Receptor Component Chromatin Binding Cytosol Receptor Corticosteroid Binding Globulin 
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  1. 1.
    O’Malley, B.W.Biochemistry, 6: 2546, 1967.PubMedCrossRefGoogle Scholar
  2. 2.
    O’Malley, B.W.McGuire, W.L.Kohler, P.O.and Korenman, S.G.Recent Progr. Hormone Res.25: 105, 1969PubMedGoogle Scholar
  3. 3.
    O’Malley, B.W.and Kohler, P.O.Proc. Nat. Acad. Sci. U.S.A.58: 2359, 1967.CrossRefGoogle Scholar
  4. 4.
    O’Malley, B.W.and McGuire, W.L.J. Clin. Invest.47:654, 1968.PubMedCrossRefGoogle Scholar
  5. 5.
    O’Malley, B.W.McGuire, W.L.and Middleton, P.A.Endocrinology, 81\: 677, 1967.PubMedCrossRefGoogle Scholar
  6. 6.
    O’Malley, B.W.Spelsberg, T.C.Schrader, W.T.Chytil, F.and Steggles, A.W.Nature, 235.: 14l, 1972.Google Scholar
  7. 7.
    O’Malley, B.W.and McGuire, W.L.Endocrinology, 84: 63, 1969.PubMedCrossRefGoogle Scholar
  8. 8.
    Hahn, W.E.Church, R.B.Gorbman, A.and Wilmot, L.Gen. Comp. Endocrinology, 11:\ U38, 1968.Google Scholar
  9. 9.
    O’Malley, B.W.Rosenfeld, G.C.Comstock, J.P.and Means, A.R.Nature, 1972, in press.Google Scholar
  10. 10.
    O’Malley, B.W.Rosenfeld, G.C.Comstock, J.P.and Means, A.R.Acta Endocrinologica, 1972, in press.Google Scholar
  11. 11.
    Means, A.R.Comstock, J.P.Rosenfeld, G.C.and O’Malley, B.W.Proc. Nat. Acad. Sci. U.S.A.69: ll46, 1972.CrossRefGoogle Scholar
  12. 12.
    Korenman, S.G.and O,Malley, B.W.J. Cell Biol. 40: 8, 1969.CrossRefGoogle Scholar
  13. 13.
    O’Malley, B.W.Toft, D.O.and Sherman, M.R.J. Biol. Chem.2k6 : 1117, 1971.Google Scholar
  14. 14.
    Toft, D.O.and O’Malley, B.W.Endocrinology, 90: l04l, 1972.CrossRefGoogle Scholar
  15. 15.
    O’Malley, B.W.Sherman, M.R.and Toft, D.O.Proc. Nat. Acad. Sci. U.S.A.67501, 1970.CrossRefGoogle Scholar
  16. 16.
    Spelsberg, T.C.Steggles, A.W.and O’Malley, B.W.J. Biol. Chem.246; 1+188.Google Scholar
  17. 17.
    Spelsberg, T.C.Hnilica, L.S.and Ansevin, A.T.Biochim. Biophys. Acta,228: 550, 1971.PubMedGoogle Scholar
  18. 18.
    Bekhor, I.Kung, G.M.and Bonner, J.J. Mol. Biol.39: 351, 1969.PubMedCrossRefGoogle Scholar
  19. 19.
    Chytil, Fand Spelsberg, T.C.Nature,233: 215, 1971.PubMedGoogle Scholar
  20. 20.
    Spelsberg, T.C.Steggles, A.W.Chytil, F.and O’Malley, B.W.J. Biol. Chem.247: 1368, 1972.PubMedGoogle Scholar
  21. 21.
    Musliner, T.A.and Chader, G.J.Biochem. Biophys. Acta,262: 256, 1972.Google Scholar
  22. 22.
    Yamamoto, K.R.and Alberts, B.M.Proc. Nat. Acad. Sci. U.S..69:2105, 1972.CrossRefGoogle Scholar
  23. 23.
    Baxter, J.D.Rousseau, D.G.Benson, N..C, Garcea, R.L.Ito, J.and Tomkins, G.M.Proc. Nat. Acad. Sci. U.S.A.69: 1892, 1972.CrossRefGoogle Scholar
  24. 24.
    Mainwaring, W.I.P.and Mangen, Advances in the Biosciences, ed. Raspe, G. (Pergamon-Vieweg, Braunschweig, Germany), Vol. 7, PP 165–178, 1971.Google Scholar
  25. 25.
    Toft, D.O.This Volume, p. 85, 1973.Google Scholar
  26. 26.
    Korenman, S.G.and Rao, B.R.Proc. Nat. Acad. Sci. U.S.A.61:1028, 1968.CrossRefGoogle Scholar
  27. 27.
    Puca, G.A.Nola, E.Sica, V.and Bresciani, F.Biochemistry, 10: 3769, 1971.PubMedCrossRefGoogle Scholar
  28. 28.
    DeSombre, E.R.Puca, G.A.and Jensen, E.V.Proc. Nat. Acad. Sci. U.S.A.64: 148, 1969.CrossRefGoogle Scholar
  29. 29.
    Schrader, W.T.and O’Malley, B.W.J. Biol. Chem.247: 51, 1972.Google Scholar
  30. 30.
    Korenman, S.G.Endocrinology, 87: 1119, 1970.CrossRefGoogle Scholar
  31. 31.
    Schrader, W.T.Toft, D.O.and O’Malley, B.W.J. Biol. Chem.247; 2401, 1972.PubMedGoogle Scholar
  32. 32.
    Scatchard, G.Ann. N.Y. Acad. Sci.51: 660, 1949.CrossRefGoogle Scholar
  33. 33.
    Clemens, L.E.and Kleinsmith, L.J.Nature,237: 204, 1972.Google Scholar
  34. 34.
    Present Addresses of the Authors: B. W. O’Malley and W. T. Schrader, Department of Cell Biology, Baylor College of Medicine, Houston, Texas; T. C. Spelsberg, Mayo Clinic, Rochester, Minnesota.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Bert W. O’Malley
    • 1
  • William T. Schrader
    • 1
  • Thomas C. Spelsberg
    • 1
  1. 1.Departments of Obstetrics-Gynecology, Biochemistry and MedicineVanderbilt University School of Medicine NashvilleUSA

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