Estrogen Receptor Transformation and Nuclear RNA Synthesis

  • Elwood V. Jensen
  • Suresh Mohla
  • Peter I. Brecher
  • Eugene R. DeSombre
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 36)


Studies from many laboratories (l) have demonstrated that the characteristic affinity of estrogen-responsive tissues for the hormone, both in vivo and in vitro, results from their content of specific estrogen-binding proteins called estrogen receptors or estrophiles. The interaction of estradiol with target tissues, such as uterus, takes place by a sequential mechanism in which the hormone first combines with an extranuclear receptor protein to form a complex which, by a temperature-dependent process, is translocated to the nucleus where most of the incorporated steroid becomes localized (Fig. 1).


Soluble Enzyme Liver Nucleus Cytosol Complex Bovine Plasma Albumin Uterine Cytosol 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Elwood V. Jensen
    • 1
  • Suresh Mohla
    • 1
  • Peter I. Brecher
    • 1
  • Eugene R. DeSombre
    • 1
  1. 1.The Ben May Laboratory for Cancer ResearchThe University of ChicagoChicagoUSA

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