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Biochemical Changes in Mitochondria as a Mechanism in Metabolic Tolerance to Ethanol

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Alcohol Intoxication and Withdrawal I

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 35))

Abstract

Ethanol when administered to animals or humans produces a variety of biochemical and pharmacological effects. Some of these effects are due to ethanol per se and others due to its metabolites. The relative significance of these effects depends on the quantity of ethanol administered. Research done over the last 10 years has furnished considerable knowledge regarding the metabolism of ethanol and the biochemical and pharmacological effects of short-term ethanol consumption, as reviewed elsewhere (Rawat, 1969). Although, in the past, effects of excess long-term ethanol consumptions have been investigated on the morphological and histological changes in various organs of the body; much attention to biochemical changes has not been given. Advances in structural techniques like electron microscopy have mainly contributed to the understanding of ultrastructure changes induced by ethanol (Popper and Schaffner, 1970).

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Authors and Affiliations

  1. Downstate Medical Center, State University of New York, New York, USA

    Arun K. Rawat Ph.D.

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  1. Arun K. Rawat Ph.D.
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Editors and Affiliations

  1. Department of Psychiatry, Downstate Medical Center, Brooklyn, New York, USA

    Milton M. Gross

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© 1973 Plenum Press, New York

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Rawat, A.K. (1973). Biochemical Changes in Mitochondria as a Mechanism in Metabolic Tolerance to Ethanol. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal I. Advances in Experimental Medicine and Biology, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3234-3_9

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  • DOI: https://doi.org/10.1007/978-1-4684-3234-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3236-7

  • Online ISBN: 978-1-4684-3234-3

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