Skip to main content
SpringerLink
Log in

Effects of Ethanol on Liver Metabolism

  • Chapter
Alcohol Intoxication and Withdrawal I

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 35))

Abstract

Changes in the liver level of lipids and fatty acids occur as results of either acute or chronic administration of ethanol, but the mechanism of such changes is not completely known. Theoretically, there are several possible mechanisms which may explain this process: e.g., ethanol may stimulate the synthesis of hepatic triglycerides from peripheral and administered fatty acids and glycerol (Mallov, 1957; Di Luzio, 1958; Horning et al., 1960; Nikkila & Ojala, 1963; Scheig & Isselbacher, 1965; Kessler & Mishkin, 1966) or it may stimulate fatty acid synthesis in the liver as suggested by Lieber and Schmidt (1961; Lieber et al., 1959). The accumulation of lipids may also be produced by suppressing the oxidation of fatty acids (Majchrowicz & Quastel, 1959, 1961, 1963; Reboucas & Isselbacher, 1961; Wooles, 1966; Fex & Olivecrona, 1968) in the liver or by suppression of lipid release from the liver (Schapiro et al., 1964; Bezman-Tarcher, 1966).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abraham, S., P. Hirsch and I. Chaikoff, J. Biol. Chem. 211:31, 1954.

    Google Scholar 

  • Abraham, S., K. J. Matthes and I. L. Chaikoff, Biochem. Biophys. Acta. 36:556, 1959.

    Article  Google Scholar 

  • Alexander, N. M., Scheig, R. and Klatskin, G., J. Lip. Res. 7:197, 1966.

    Google Scholar 

  • Ammon, H.P.T., Naunyn-Schmiedebergs Arch. Exp. Path. Pharmak. 251:114, 1965.

    Article  Google Scholar 

  • Ammon, H.P.T. and C. J. Estler, Klin. Wschr. 44:651, 1966.

    Google Scholar 

  • Ammon, H.P.T., C. J. Estler and F. Heim, Arch. int. Pharmacodyn. 159:258, 1966.

    Google Scholar 

  • Ammon, H.P.T., F. Heim, C. J. Estler, G. Fickeis and M. Wagner, Biochem. Pharmacol. 16:1533, 1967.

    Article  Google Scholar 

  • Ariyoshi, T., E. Takabatake and H. Remmer, Life. Sci. 9, Part II, 361, 1970.

    Article  Google Scholar 

  • Barboriak, J. J., Life Sci. 5:237, 1966.

    Article  Google Scholar 

  • Bezman-Tarcher, A., P. J. Nestel, J. M. Felts and R. J. Havel, J. Lip. Res. 7:248, 1966.

    Google Scholar 

  • Bornstein, A. and A. Loewy, Biochem. Z. 191:271, 1927.

    Google Scholar 

  • Brady, R. O., R. M. Bradley and E. G. Trams, J. Biol. Chem. 235:3093, 1960.

    Google Scholar 

  • Brodie, B. B., W. M. Butler, Jr., Marjorie C. Horning, R. P. Maickel and Harriet M. Maling, Am. J. Clin. Nutr. 9:432, 1961.

    Google Scholar 

  • Brodie, B. B. and R. P. Maickel, Ann. N.Y. Acad. Sci. 104:1049, 1963.

    Google Scholar 

  • Brown, E. A., J. M. Hunter and Harriet M. Maling, Proc. Soc. Exper. Biol. Med. 122:1079, 1966.

    Google Scholar 

  • Burton, R. M. and E. R. Stadtman, J. Biol. Chem. 202:873, 1953.

    Google Scholar 

  • Di Luzio, N. R., Am. J. Physiol. 194:453, 1958.

    Google Scholar 

  • Di Luzio, N. R., Life Sci. 4:1373, 1965.

    Article  Google Scholar 

  • Farber, E., K. H. Shull, S. Villa-Trevino, B. Lombardi and M. Thomas, Nature; Lond. 203:34, 1964.

    Article  Google Scholar 

  • Fex, G. and Th. Olivecrona, Acta. physiol. scand. 75:78, 1968.

    Article  Google Scholar 

  • Forsander, O. A., Biochem. J. 98:244, 1966.

    Google Scholar 

  • Forsander, O. A. and J. J. Himberg, Metabolism 18:776, 1969.

    Article  Google Scholar 

  • Forsander, O. A. and K. O. Lindros, Acta Chem. Scand. 21:2568, 1967.

    Article  Google Scholar 

  • Forsander, O. A., N. Raiha, M. Salaspuro and P. Maenpaa, Biochem. J. 94:259, 1965.

    Google Scholar 

  • Freinkel, N., R. A. Arky, D. L. Singer, A. K. Cohen, S. J. Bleicher, J. B. Anderson, C. K. Silbert and A. E. Foster, Diabetes 14:350, 1965.

    Google Scholar 

  • French, S. W., Proc. Soc. Exp. Biol. Med. 121:681, 1966.

    Google Scholar 

  • Fritz, I. B., Physiol. Rev. 41:52, 1961.

    Google Scholar 

  • Gajdos, A., M. Gajdos-Torok, A. Palma-Carlos and L. Palma-Carlos, C. R. Soc. Biol. (Paris) 159:2185, 1965.

    Google Scholar 

  • Higgins, H. L., J. Pharmacol. 9:441, 1917.

    Google Scholar 

  • Horning, Marjorie G., E. A. Williams, Harriet M. Maling and B. B. Brodie, Biochem. Biophys. Res. Comm. 3:635, 1960.

    Article  Google Scholar 

  • Horning, Marjorie G., M. Wakabayashi and Harriet M. Maling, Proc. 1st Internat* Pharmacol. Meet., p. 13, The MacMillan Co., 1963.

    Google Scholar 

  • Hyams, D. E. and K. J. Isselbacher, Nature 204:1196, 1964.

    Article  Google Scholar 

  • Isselbacher, K. J. and N. J. Greenberger, New Engl. J. Med. 270:351, 402, 1964.

    Article  Google Scholar 

  • Jones, D. P., M. S. Losowski, C. S. Davidson and C. S. Lieber, J. Clin. Investigation 42:945, 1963.

    Article  Google Scholar 

  • Kessler, J. I. and S. Yalovsky-Mishkin, J. Lip. Res. 7:772, 1966.

    Google Scholar 

  • Klainer, L. M., Y. M. Chi, S. L. Freidberg, T. W. Rail and E. W. Sutherland, J. Biol. Chem. 237:1239, 1962.

    Google Scholar 

  • Krebs, H. A., R. A. Friedland, R. Hems and Marion Stubs, Biochem. J. 112:117, 1969.

    Google Scholar 

  • Langdon, R. G., J. Amer. Chem. Soc. 77:5190, 1955.

    Article  Google Scholar 

  • Lehninger, A. L., The Mitochondria, New York: W. A. Benjamin, Inc., p. 90, 1964.

    Google Scholar 

  • Leloir, L. F. and J. M. Munoz, Biochem. J. 32:299, 1938.

    Google Scholar 

  • Lieber, C. S., Leonore M. DeCarli and R. Schmid, Biochem. Biophys. Res. Comm. 1:302, 1959.

    Article  Google Scholar 

  • Lieber, C. S. and R. Schmid, J. Clin. Invest. 40:394, 1961.

    Article  Google Scholar 

  • Lieber, C. S. and C. S. Davidson, Am. J. Med. 33:319, 1962.

    Article  Google Scholar 

  • Lieber, C. S. Progress in Liver Diseases, Popper, H. and F. Schaffner (eds), Grune and Stratton, New York and London, 1965, Chapter XI, p. 134.

    Google Scholar 

  • Lundquist, F., Nature 193:579, 1962.

    Article  Google Scholar 

  • Lundquist, F., U. Fugmann, H. Rasmussen, and T. Svendsen, Biochem. J. 84:281, 1962.

    Google Scholar 

  • Lundquist, F., N. Tygstrup, K. Winkler, K. Mellemgaard and S. Munck-Petersen, J. Clin. Invest. 41:955, 1962a.

    Article  Google Scholar 

  • Maickel, R., H. Sussman, K. Yamada and B.B. Brodie, Life Sci. 3:310, 1963.

    Google Scholar 

  • Mallov, S. and J. L. Bloch, Am. J. Physiol. 184:29, 1956.

    Google Scholar 

  • Mallov, S., Am. J. Physiol. 189:428, 1957.

    Google Scholar 

  • Majchrowicz, E. and J. H. Quastel, reported by J. H. Quastel, Quart. J. Stud. Alc. 20:428, 1959.

    Google Scholar 

  • Majchrowicz, E. and J. H. Quastel, Canad. J. Biochem. Physiol. 39:1895, 1961.

    Article  Google Scholar 

  • Majchrowicz, E. and J. H. Quastel, Canad. J. Biochem. Physiol. 41:793, 1963.

    Article  Google Scholar 

  • Majchrowicz, E., Proc. Soc. Exper. Biol. Med. 115:615, 1964.

    Google Scholar 

  • Majchrowicz, E., Canad. J. Biochem. 43:1041, 1965.

    Article  Google Scholar 

  • Majchrowicz, E., Fifth International Congress on Pharmacology, San Francisco, 1972.

    Google Scholar 

  • Mattie, H., Acta Physiol. Pharmacol. Neerl. 12:1, 1963.

    Google Scholar 

  • Nikkila, E. A. and Karina Ojala, Proc. Soc. Exper. Biol. Med. 113:814, 1963.

    Google Scholar 

  • Rawat, A. K., Europ. J. Biochem. 6:585, 1968.

    Article  Google Scholar 

  • Rizack, M. A., J. Biol. Chem. 239:392, 1964.

    Google Scholar 

  • Reboucas, G. and K. J. Isselbacher, J. Clin. Invest. 40:1355, 1961.

    Article  Google Scholar 

  • Rothschild, M. A., M. Oratz, J. Mongelli and S. S. Schreiber, J. Clin. Invest. 50, 1812, 1971.

    Article  Google Scholar 

  • Rubin, E., Diane S. Beattie and C. S. Lieber, Lab. Invest. 23: 620, 1970.

    Google Scholar 

  • Sardesai, V. M. and J. M. Orten, J. Nutr., 96:241, 1968.

    Google Scholar 

  • Schapiro, R. H., Gladys D. Drummey, Y. Shimizu and K. J. Isselbacher, J. Clin. Invest. 43:1338, 1964.

    Article  Google Scholar 

  • Scheig, R. and K. J. Isselbacher, J. Lip. Res. 6:269, 1965.

    Google Scholar 

  • Siekevitz, P., J. Biol. Chem., 195:549, 1952.

    Google Scholar 

  • Siperstein, M. D. and V. Fagan, J. Clin. Invest. 37:188, 1958.

    Google Scholar 

  • Slater, T. F., Barbara C. Sawyer and Ursula D. Strauli, Biochem. J. 93:267, 1964.

    Google Scholar 

  • Smith, Marion E. and H. W. Newman, J. Biol. Chem. 234:1544, 1959.

    Google Scholar 

  • Sutherland, E. W., I. Oye and R. W. Butcher, Advances in Hormone Research 21:623, 1965.

    Google Scholar 

  • Tewari, S. and E. P. Noble, Brain Research 26:469, 1971.

    Google Scholar 

  • Umbreit, W. W., R. H. Burris and J. F. Stauffer, Manometric Techniques, Burgess Publishing Co., Minneapolis, Minn., 1957.

    Google Scholar 

  • Vaughan, Martha, J. Biol. Chem. 235:3049, 1960.

    Google Scholar 

  • Vaughan, Martha and D. Steinberg, J. Lipid Res. 4:193, 1963.

    Google Scholar 

  • Walker, Jennifer E.G. and Ellen R. Gordon, Biochem. J. 119:511, 1970.

    Google Scholar 

  • Wakil, S. J., D. E. Green, S. Mil and H. R. Mahler, J. Bio Chem. 207:631, 1954.

    Google Scholar 

  • Wallgren, H., Biochem. Pharmacol. 6:195, 1961.

    Article  Google Scholar 

  • Warembourg, H., G. Biserte, J. Jaillard, G. Sezille and P. Scherperseel, Rev. Europ. Etudes Clin. et Biol. 15:649, 1970.

    Google Scholar 

  • Westerfeld, W. W., Texas Rep. Biol. & Med., 13:559, 1955.

    Google Scholar 

  • Westerfeld, W. W., Am. J. Clin. Nutr. 9:426, 1961.

    Google Scholar 

  • Williamson, J. R., R. Scholtz, E. T. Browning, R. G. Thurman and M. H. Fukami, J. Biol. Chem 244:5044, 1959.

    Google Scholar 

  • Wooles, W. R., Life Sci. 5:267, 1966.

    Article  Google Scholar 

  • Zakim, P., Life Sci. 4:209, 1965.

    Article  Google Scholar 

  • Zakim, D., Arch. Biochem. Biophys. 111:253, 1965a.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biochemistry Program, Laboratory of Alcohol Research, National Institute on Alcohol Abuse and Alcoholism N.I.M.H., Washington, D. C., 20032, USA

    Edward Majchrowicz

Authors
  1. Edward Majchrowicz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Psychiatry, Downstate Medical Center, Brooklyn, New York, USA

    Milton M. Gross

Rights and permissions

Reprints and permissions

Copyright information

© 1973 Plenum Press, New York

About this chapter

Cite this chapter

Majchrowicz, E. (1973). Effects of Ethanol on Liver Metabolism. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal I. Advances in Experimental Medicine and Biology, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3234-3_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3234-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3236-7

  • Online ISBN: 978-1-4684-3234-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation