Abstract
“Platelet Factor-4” (PF-4) indicates one or more factors exhibiting several biological functions (for review, see ref.3), the best known of which is the ability of neutralizing the anti- clotting activity of heparin; PF-4 is also able to neutralise the anticlotting activity of some fibrinogen degradation products and to induce non-enzymatic polymerization of fibrinogen and its derivatives, a phenomenon known as “paracoagulation”.
Supported in part by grant n. 1216 of the Fonds voor Wetenschappelijk Geneeskundig Onderzoek, Belgium.
On leave of absence from the Laboratory of Blood Coagulation (Prof. B. Bizzi), Department of Internal Medicine (Prof.R.Breda), Università Cattolica, Roma, Italy. Fellow of the Ministero della Pubblica Istruzione of Italy.
On leave of absence from the Department of Clinical Chemistry (Dr. A. Wolanska), Institute of Tuberculosis, Warsaw, Poland. Fellow of the Belgian Cultural Exchange Program.
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Donati, M.B., Palester-Chlebowczyk, M., de Gaetano, G., Vermylen, J. (1972). Platelet Factor-4. Methods of Study. In: Mannucci, P.M., Gorini, S. (eds) Platelet Function and Thrombosis. Advances in Experimental Medicine and Biology, vol 34. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-3231-2_19
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