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Decreased 2,3-Diphosphoglycerate and Reduced Oxygen Delivery Following Massive Transfusion and Septicemic Shock

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Neurohumoral and Metabolic Aspects of Injury

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 33))

Abstract

Oxygen delivery has been demonstrated to be inadequate in patients in septicemic shock as manifested by an elevated mixed venous O2 saturation (1). The subsequent narrow arterio-venous (A-V) O2 content difference has been attributed to pre-capillary A-V shunting (2). Other possible causes could be decreased mitochondrial utilization of O2 (3) and decreased release of O2 from hemoglobin (4).

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Author information

Authors and Affiliations

  1. Departments of Pediatrics and Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA

    Harvey J. Sugerman, Leonard D. Miller, Maria Delivoria-Papadopoulos & Frank A. Oski

Authors
  1. Harvey J. Sugerman
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  2. Leonard D. Miller
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  3. Maria Delivoria-Papadopoulos
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  4. Frank A. Oski
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Editor information

Editors and Affiliations

  1. Experimental Research Department, Semmelweis Medical University, Budapest, Hungary

    Arisztid G. B. Kovách

  2. MRC Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey, UK

    H. B. Stoner

  3. Department of Physiology and Biophysics, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, USA

    John J. Spitzer

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© 1973 Plenum Press, New York

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Sugerman, H.J., Miller, L.D., Delivoria-Papadopoulos, M., Oski, F.A. (1973). Decreased 2,3-Diphosphoglycerate and Reduced Oxygen Delivery Following Massive Transfusion and Septicemic Shock. In: Kovách, A.G.B., Stoner, H.B., Spitzer, J.J. (eds) Neurohumoral and Metabolic Aspects of Injury. Advances in Experimental Medicine and Biology, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3228-2_45

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  • DOI: https://doi.org/10.1007/978-1-4684-3228-2_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3230-5

  • Online ISBN: 978-1-4684-3228-2

  • eBook Packages: Springer Book Archive

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