Time Course of Metabolite and Enzyme Changes in Hypoxic Conditions

Abstract

Tissue hypoxia of shock is often characterized by metabolites of anaerobic glycolysis released into the blood plasma auch as lactic and pyruvic acids and by the so-called “excess lactate” of Huckabee. (Huckabee 1958; Rosenberg et al., 1961; Peretz et al., 1965). Release of lysosomal and cytoplasmic enzymes into the circulation also occurs in hemorrhagic shock. We have shown earlier that their plasma level correlates well with the severity of shock (Gergely et al., 1970; Barankay and Petri 1969). According to the investigations of Schmidt during hypoxic damage of isolated, perfused organs a significant release of enzymes and metabolites takes place (Schimdt et al., 1966). These substances appear in the perfusate after the lapse of a certain period of time depending on their intracellular localization, binding, etc.