Abstract
Hypovolemic shock of the dogs is regularly accompanied by hemorrhagic necrosis of the intestinal epithelium. According to Lillehei et al., (1962), Seikurt (1970) and Lefler (1970) hemorrhagic enteritis appears to play an etiologic role in the shock state. Although the cause of the widespread intestinal damage is not yet clear, hemodynamic changes undoubtedly play a relevant role in its development. It was repeatedly shown (Fine, 1967; Lillehei et al., 1967; Bashour & McClelland, 1967) that blood flow through organs of the splanchnic area decreases considerably both in hemorrhagic and other forms of shock. Among possible etiologic factors, the long-lasting hypotension, the increased sympathetic activity (Chien & Hitzig, 1964; Fedina et al., 1965; Thämer et al. 1969) and, in dogs only, the constriction of the hepatic sphincters (Conn & Parsons, 1950; MacLean et al., 1956; Knisely et al., 1957) should be considered. However the precise role of the hepatic sphincters in initiating necrosis of the intestinal epithelium has not yet been established. In order to clarify their role we studied the effect of porto-caval shunt on the development of shock in anesthetized dogs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bashour, F.A. & McClelland, R. (1967) Gastroenterology.52,461.
Chien, S. & Hitzig, B. (1964) Am.J.Phys. 206, 21.
Cohn, R. & Parsons, H. (1950) Am. J. Phys. 160, 347.
Fedina, L., Kovach, A.G.B. & Vanik, M. (1965) Acta physiol. hung. Suppl. 26, 35.
Fine, J. (1967) Gastroenterology 52, 454.
Gouriz, J.T. & Nickerson, M. (1965) In: Shock and Hypotension. Ed. L.C. Mills and J.H. Moyer. Grune & Stratton, New York-London.
Knisely, M., Harding, F. & Debacker, H. (1957) Science, 125, 602.
Kovách, A.G.B. & Mitsányi, A. (1964) Wien Med Wschr.114,401.
Leffer, A. (1970) Fed. Proc. 29, 1836.
Lillehei, R.C., Dietzman, R. & Movsas, S. (1967) Gastroenterology 52, 468.
Lillehei, R.C., Longbeam, J.K. & Rosenberg, J.C. (1962) In: Shock, Pathogenesis and Therapy. Ed. K.D. Bock, Berlin, Göttingen, Heidelberg, Springer Verl. p. 106.
MacLean, L.D., Weil, M.H., Spink, W.W. & Visscher, M.B. (1956) Proc.Soc.Exp.Biol.Med. 92, 602.
Selkurt, E. (1970) Fed. Proc. 29, 1832.
Thämer, V., Weidinger, H. & Kirchner, F. (1969). Z. Krelslaufforsen 58, 472.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Plenum Press, New York
About this chapter
Cite this chapter
Hamar, J., Gergely, M., Nyáry, I., Kovách, A.G.B. (1973). Effect of Porto-Caval Shunt on Splanchnic Blood Flow in Hemorrhage. In: Kovách, A.G.B., Stoner, H.B., Spitzer, J.J. (eds) Neurohumoral and Metabolic Aspects of Injury. Advances in Experimental Medicine and Biology, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3228-2_31
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3228-2_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3230-5
Online ISBN: 978-1-4684-3228-2
eBook Packages: Springer Book Archive