Abstract
Hemorrhage as a stress stimulus activates the endocrine system which results in an increase of circulating catecholamines (7), glucocorticoids and ACTH (8). These hormones induce various metabolic changes including hyperglycemia which regularly appears in the early period of hemorrhagic shock in well-fed animals (l7), being predominantly mediated by catecholamines, whereas glucocorticoids contribute to its intensity and persistence (9). The hyperglycemia acts as a physiological stimulus for insulin secretion, but in the presence of an increased blood catecholamine level the secretory response of the islets is blocked (1,14). The activation of the endocrine system with resulting metabolic changes may increase the demand for insulin and its absolute or relative deficiency may seriously jeopardize survival in shock.
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© 1973 Plenum Press, New York
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Vigaš, M., Haist, R.E., Bauer, F., Drucker, W.R. (1973). Insulin Secretion during Hemorrhagic Shock. In: Kovách, A.G.B., Stoner, H.B., Spitzer, J.J. (eds) Neurohumoral and Metabolic Aspects of Injury. Advances in Experimental Medicine and Biology, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3228-2_18
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DOI: https://doi.org/10.1007/978-1-4684-3228-2_18
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