Potential Effects of Hemoglobin Concentration on Red Cell Metabolism Together with Observations on Red Cell Metabolic Differences Between Men and Women
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One of our major interests has been the glycolytic control mechanisms in the red cell which determine DPG levels normally and during hypoxic stress. We have increasingly utilized the method of assaying the measurable intermediates throughout the glycolytic pathway, along the lines suggested by Yoshikawa and Minakami (1968), in order to determine the key enzymatic step or steps which bring about changes in DPG. Through these studies we have begun to discern a rather consistent pattern, suggesting that the activity of hexokinase, already known to be one of the key regulators of erythrocyte glycolysis (Rapoport, 1968; Yoshikawa and Minakami, 1968), may be a very important factor in regulating DPG levels, in a number of circumstances. This pattern is illustrated in papers on anemia (Oelshlegel, et al. 1972) and altitude adaptation (Moore, et al. 1972) in this volume, but we would also like to illustrate it in the first part of this paper in differences between normal men and women.
KeywordsHemoglobin Concentration Chronic Hypoxia Oxygen Affinity Hereditary Spherocytosis Hexokinase Activity
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