The Two Bohr Effects: Physiological Consequences of Ligand Interaction with Hemoglobin

  • B. Wranne
  • R. Woodson
  • J. Detter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)


Factors affecting oxygen transport to tissue are cardiac output and its distribution, blood oxygen content, and affinity of hemoglobin for oxygen. Hemoglobin-oxygen affinity, in turn, depends upon pH, CO2, and DPG. The physiologic significance of such alterations in oxygen affinity of hemoglobin has been a matter of some interest. In the course of studying the in vivo consequences of increased hemoglobin-oxygen affinity, we recently noted that rats with a 15 mm Hg decrease in PO2 due to DPG depletion were able to perform in a maximal exercise test as well or very nearly as well as rats with normal hemoglobin-oxygen affinity. By contrast, rats with normovolemic anemia showed a marked reduction in work capacity.


Base Excess Oxygen Affinity Maximal Exercise Test Human Haemoglobin Bohr Effect 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • B. Wranne
    • 1
    • 2
  • R. Woodson
    • 1
    • 2
  • J. Detter
    • 1
    • 2
  1. 1.Department of MedicineUniversity of Washington School of MedicineUSA
  2. 2.Department of Laboratory MedicineUniversity of Washington School of MedicineUSA

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