Abstract
Factors affecting oxygen transport to tissue are cardiac output and its distribution, blood oxygen content, and affinity of hemoglobin for oxygen. Hemoglobin-oxygen affinity, in turn, depends upon pH, CO2, and DPG. The physiologic significance of such alterations in oxygen affinity of hemoglobin has been a matter of some interest. In the course of studying the in vivo consequences of increased hemoglobin-oxygen affinity, we recently noted that rats with a 15 mm Hg decrease in PO2 due to DPG depletion were able to perform in a maximal exercise test as well or very nearly as well as rats with normal hemoglobin-oxygen affinity. By contrast, rats with normovolemic anemia showed a marked reduction in work capacity.
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© 1972 Plenum Press, New York
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Wranne, B., Woodson, R., Detter, J. (1972). The Two Bohr Effects: Physiological Consequences of Ligand Interaction with Hemoglobin. In: Brewer, G.J. (eds) Hemoglobin and Red Cell Structure and Function. Advances in Experimental Medicine and Biology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3222-0_34
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DOI: https://doi.org/10.1007/978-1-4684-3222-0_34
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