Studies on the Ability of Stored Blood to Transport Oxygen In Vivo

  • S. Balcerzak
  • J. Guy
  • E. Metz
  • P. Bromberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)


Blood stored in acid-citrate-dextrose (ACD) shows a progressive increase in oxygen affinity primarily as the result of a decrease in red cell 2,3-diphosphoglycerate (DPG)1. Restoration of DPG levels (and presumably normal blood oxygen affinity) appears to occur promptly after transfusion of ACD-stored, DPG- depleted blood. Delayed restoration of DPG and oxygen affinity may impair oxygen delivery. Beutler and Wood reported that DPG values returned to nearly 50 percent of normal within 4 hours.2 Others have indicated that at least 25 percent of the final DPG level was achieved within 8 hours after completion of transfusion.3 Whether the rate of DPG restoration is significantly variable from patient to patient is uncertain because only a few patients have been reported.


Oxygen Tension Exchange Transfusion Fresh Blood Oxygen Affinity Arterial Oxygen Tension 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • S. Balcerzak
    • 1
  • J. Guy
    • 1
  • E. Metz
    • 1
  • P. Bromberg
    • 1
  1. 1.Department of MedicineOhio State UniversityColumbusUSA

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